Geometric isomers of vitamin E; tocotrienols Sample Clauses

Geometric isomers of vitamin E; tocotrienols γ-T is found in nuts, seeds and vegetable oils and has been found to promote health and protect against disease predominantly defending against reactive nitrogen species (NOS). Furthermore it has been found to reduce inflammation, prevent certain types of cancer and activate genes that protect against Alzheimer’s disease. γ-T has anti-inflammatory properties as it inhibits XXX-2, this is a property not shared with α-T. γ-T also acts as a powerful nucleophile that traps electrophilic mutagens. Thus γ-T may protect lipids, DNA and proteins from peroxynitrte- dependent damage (Brielius-Flohe & Xxxxxx., 1999). This point demonstrates the sensitivity that the geometric structures of vitamin E have on their respective therapeutic properties. In this case one methyl group changes anti-inflammatory properties from decreasing binding affinity between neutrophil and endothelial (α-T) to the inhibition of XXX-2 (γ-T) with the first acting as a signalling molecule and the second as an enzyme binding inhibitor. Recent studies have shown that the reason the α-T has the highest bioactivity is due to it preferentially appearing in plasma after passage through the liver. The reason for this is thought to be α-T is binding to the α-tocopherol transport protein (Brielius-Flohe & Xxxxxx., 1999). Although this is not directly relevant to oral healthcare it does show that the human body is preferentially increasing α-T in plasma for some reason, possibly because it is the tocopherol with the most beneficial properties.
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