Levosimendan definition

Levosimendan means (-)(R)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile.
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Levosimendan means (-)(R)-[[4-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)phenyl]-hydrazono]propanedinitrile. “LCOS” means low cardiac output syndrome.
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Examples of Levosimendan in a sentence

  • Orion owns and controls certain patent rights and proprietary information with respect to Levosimendan and the Product.

  • Levosimendan is a promising new agent for the perioperative treatment of cardiac surgery patients to maintain hemodynamic performance and preserve myocardium function and prevent end organ damage.

  • For the avoidance of doubt it is expressly agreed that Orion shall have no obligation whatsoever (i) to carry out or have carried out any trial or study relating to Levosimendan or the Product whether requested by Licensee or any Regulatory Approval; or (ii) to prepare any data, information or documentation that is not readily available to Orion.

  • Orion shall promptly provide Licensee with copies of all data, information and documentation existing on the Effective Date regarding the Product and/or Levosimendan necessary for Licensee to obtain and maintain Regulatory Approval for the Product in the Territory.

  • Levosimendan is extensively metabolized before excretion into urine and feces.

  • Investigational product, dose and mode of administration: Levosimendan, supplied as a concentrated solution (2.5 mg/mL), or matching placebo will be administered intravenously at 0.2 µg/kg/min for the first hour with adjustment of the dose to 0.1 µg/kg/min for an additional 23 hours.

  • Levosimendan has been marketed in Sweden since 2000 for acute decompensated heart failure.

  • Levosimendan exerts its positive inotropic effect by increasing calcium sensitivity of myocytes by binding to cardiac troponin C in a calcium-dependent manner.

  • Levosimendan has been assessed in numerous clinical studies by independent investigators throughout the world.

  • Levosimendan or matching placebo will be dispensed according to the kit number provided by the IVRS (see Section 5.2, Procedures).

Related to Levosimendan

  • Panchayat means an institution (by whatever name called) of self-government constituted under article 243B, for the rural areas;

  • Seaplane means an aircraft that is capable of landing and taking off on the water.