3TC definition
Examples of 3TC in a sentence
For example, Licensee shall not sell to a Gilead Distributor (X) a Product containing TDF, FTC and efavirenz, unless Gilead has granted such distributor the right to sell a branded product containing TDF, FTC and efavirenz in such country in the Territory, or (Y) a Product containing both TDF and 3TC.
For example, Licensee shall not sell to a Gilead Distributor (X) a Product containing TDF, emtricitabine (FTC) and efavirenz in a particular country in the TDF-TAF Territory, unless Gilead has granted such distributor the right to sell a branded product containing TDF, FTC and efavirenz in such country in the TDF-TAF Territory, or (Y) a Product containing both TDF and 3TC or both TAF and 3TC.
Since Emtriva and lamivudine (3TC) are comparable in their structure, resistance profiles, and efficacy and safety as part of multi-drug regimens, existing data from the use of lamivudine and Viread in combination have been extrapolated to support use of Truvada tablets for the treatment of HIV-1 infection in adults.
For example, Licensee shall not sell to a Gilead Distributor (X) a Product containing TAF, emtricitabine (FTC) and efavirenz in a particular country in the TAF Territory, unless Gilead has granted such distributor the right to sell a branded product containing TAF, FTC and efavirenz in such country in the TAF Territory, or (Y) a Product containing both TAF and 3TC.
The proportion of patients with virologic failure was 7% in the FTC arm and 8% in the 3TC arm.
TDF should not be used with two NRTIs as a triple ARV therapy when considering a new treatment regimen, given poor results when combined with abacavir (ABC) and 3TC or ddI and 3TC for naïve patients (Gilead communication).
Pre-Clinical The antiretroviral activity of FTC has been shown to up to 10-fold greater than Epivir® (lamivudine, 3TC) against HIV‑1 clinical isolates in vitro using human peripheral blood mononuclear cells (PBMCs), macrophages and laboratory adapted T-cell lines (▇▇▇▇▇▇▇▇, 1992, ▇▇▇▇▇▇▇▇, 2003).
Study 903 is an ongoing trial, with a 144-week randomized, double‑blind trial designed to compare the efficacy and safety of a treatment regimen of TDF, 3TC, and EFV to a regimen of d4T, 3TC and EFV in 600 ARV-naive subjects with HIV infection.
Rates of hepatic dysfunction were comparable between the randomized treatment arms of FTC versus 3TC.
Patients were randomized 1:2 to continue therapy with 3TC (150 mg BID) or to switch to FTC (200 mg QD).