UNDERWRITING AGREEMENTUnderwriting Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations • New York
AGREEMENT OF LEASE between SLG Graybar Mesne Lease LLC Landlord and Tiziana Life Sciences PLC Tenant Dated as of August 2, 2016 Suite 2525-28 420 Lexington Avenue New York, New YorkAgreement of Lease • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations
LEASE (this “Lease”) made as of the 2nd day of August 2016 between SLG Graybar Mesne Lease LLC having an office c/o SL Green Realty Corp., at 420 Lexington Avenue, New York, New York, 10170, hereinafter referred to as “Landlord”, and Tiziana Life Sciences PLC, a United Kingdom public limited company having an office at 18 South Street, Mayfair, London W1K 1DG, United Kingdom, hereinafter referred to as “Tenant”.
SERVICE AGREEMENTService Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations
LICENSE AND SUBLICENSE AGREEMENTLicense and Sublicense Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations • England and Wales
This License and Sublicense Agreement (“Agreement”) is made effective as of December 22, 2016 (“Effective Date”) by and between on the one hand NovImmune S.A., 14 Chemin des Aulx, Plan les Ouates, Geneva, Switzerland (“Licensor”), and Tiziana Life Sciences, 18 South Street, Mayfair, London, W1K 1DG, UK (“Licensee”). Licensor and Licensee are each hereafter referred to individually as a “Party” and together as the “Parties.”
AMENDMENT TO LEASE AGREEMENTLease Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations • Pennsylvania
THIS FIRST AMENDMENT TO LEASE AGREEMENT (“First Amendment”) is dated as of the 6 December 2017 between BUCKS COUNTY BIOTECHNOLOGY CENTER, INC., a Pennsylvania nonprofit corporation (“Lessor”) and TIZIANA THERAPEUTICS INC (“Lessee”) (collectively, the “Parties”).
DATED 29 June, 2018 HYDE PARK RESIDENCE LIMITED (1) AND TIZIANA PHARMA LIMITED (2) LEASE RELATING TO SUITE 14A, 55 PARK LANE, LONDON, W1K 1NA Lewis Silkin LLP 5 Chancery Lane Clifford’s Inn London EC4A 1BL Ref: PB8093/403.139Lease • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations
Building The building known as 55 Park Lane, London WIK 1NA of which the Premises form part and described in more detail in Part 1 of the First Schedule
EXCLUSIVE PATENT LICENSE AGREEMENT BWH Agreement No: A225080 BWH Case No: BWH 24334Exclusive Patent License Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations • Massachusetts
This Exclusive Patent License Agreement (“Agreement”) is made as of the last signature date of this Agreement, (“Effective Date”), by and between Tiziana Pharma Ltd., a company incorporated in England and Wales, having a principal place of business at 3rd Floor, 11-12 St. James Square, London, United Kingdom SW1Y 4LB (“Company”) and The Brigham and Women’s Hospital, Inc., a not-for-profit Massachusetts corporation, with a principal place of business at 75 Francis Street, Boston, Massachusetts 02115 (“Hospital”), each referred to herein individually as a “Party” and collectively as the “Parties”.
LICENSE AGREEMENTLicense Agreement • August 23rd, 2018 • Tiziana Life Sciences PLC • Pharmaceutical preparations • England and Wales
This License Agreement (“Agreement”) by and between Nerviano Medical Sciences, Viale Pasteur 10, Nerviano, Milano, Italy ( “Licensor” or “NMS”), and Tiziana Life Sciences Plc, 18 South Street, Mayfair, London W1K 1DG, United Kingdom (“Licensee” or “TIZIANA”) is made effective as of the date that the Agreement is signed by the last Party to sign below (“Effective Date”). Licensor and Licensee are each hereafter referred to individually as a “Party” and together as the “Parties.”
