0001193125-26-322160 Sample Contracts

FORM OF SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations • Delaware

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is dated as of July 28, 2026, by and among Caldera Therapeutics, Inc., a Delaware corporation (the “Company”), and each of the Persons listed on Exhibit A attached to this Agreement (each, an “Investor” and together, the “Investors”).

FORM OF REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of July 28, 2026, is entered into by and among Caldera Therapeutics, Inc., a Delaware corporation (the “Company”), Sonic Holdco, Inc., a Delaware corporation (“Parent”), and the several investors signatory hereto (individually as an “Investor” and collectively together with their respective permitted assigns, the “Investors”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Securities Purchase Agreement by and among the Company and the Investors party thereto, dated as of July 28, 2026 (as amended, restated, supplemented or otherwise modified from time to time, the “Purchase Agreement”).

FORM OF WARRANT TO PURCHASE COMMON STOCK AMENDING AGREEMENT
Warrant to Purchase Common Stock Amending Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations
FORM OF LOCK-UP AGREEMENT
Lock-Up Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations
STOCKHOLDER SUPPORT AGREEMENT
Stockholder Support Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations • Delaware

This Support Agreement (this “Support Agreement”) is being delivered on July 28, 2026 by the person or persons named on the signature pages hereto (collectively, the “Holder”), as the holder of Synlogic Shares (as defined below) of Synlogic, Inc., a Delaware corporation (“Synlogic”), to Caldera Therapeutics, Inc., a Delaware corporation (“Caldera”) and to Synlogic.

STOCKHOLDER SUPPORT AGREEMENT
Stockholder Support Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations • Delaware

This Support Agreement (this “Support Agreement”) is being delivered on July 28, 2026 by the person or persons named on the signature pages hereto (collectively, the “Holder”), as the holder of Caldera Shares (as defined below) of Caldera Therapeutics, Inc., a Delaware corporation (“Caldera”), to Synlogic, Inc., a Delaware corporation (“Synlogic”) and to Caldera.

AGREEMENT AND PLAN OF MERGER by and among: CALDERA THERAPEUTICS, INC.; SYNLOGIC, INC.; SONIC HOLDCO, INC.; YELLOWSTONE MERGER SUB, INC.; and SONIC MERGER SUB, INC.; Dated as of July 28, 2026
Merger Agreement • July 29th, 2026 • Synlogic, Inc. • Pharmaceutical preparations • Delaware

THIS AGREEMENT AND PLAN OF MERGER (this “Agreement”) is made and entered into as of July 28, 2026, by and among CALDERA THERAPEUTICS, INC., a Delaware corporation (“Caldera”), SYNLOGIC, INC., a Delaware corporation (“Synlogic”), SONIC HOLDCO, INC., a Delaware corporation (“Parent”), YELLOWSTONE MERGER SUB, INC., a Delaware corporation and a direct, wholly owned subsidiary of Parent (“Caldera Merger Sub”), and SONIC MERGER SUB, INC., a Delaware corporation and a direct, wholly owned subsidiary of Parent (“Synlogic Merger Sub”). Certain capitalized terms used in this Agreement are defined in Section 1.1.