0001193125-24-069256 Sample Contracts

Contract
Contineum Therapeutics, Inc. • March 15th, 2024 • Pharmaceutical preparations • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 6.3 AND 6.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO THE COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

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LEASE AGREEMENT
Lease Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations

THIS LEASE AGREEMENT (this “Lease”) is made this 25 day of October, 2023 (the “Effective Date”), between ARE-3535/3565 GENERAL ATOMICS COURT, LLC, a Delaware limited liability company (“Landlord”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations • New York

This Amended and Restated Registration Rights Agreement (this “Agreement”) is made as of July 9, 2021 by and between Pipeline Therapeutics, Inc., a Delaware corporation (the “Company”), and the persons listed on the attached Schedule A who are signatories to this Agreement (collectively, the “Investors”). Unless otherwise defined herein, capitalized terms used in this Agreement have the respective meanings ascribed to them in Section 1.

LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations • California

THIS LOAN AND SECURITY AGREEMENT (this “Agreement”) dated and effective as of September 1, 2020 (the “Effective Date”) between SILICON VALLEY BANK, a California corporation (“Bank”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Borrower”), provides the terms on which Bank shall lend to Borrower and Borrower shall repay Bank. The parties agree as follows:

LICENSE AGREEMENT BY AND BETWEEN JANSSEN PHARMACEUTICA NV AND PIPELINE THERAPEUTICS, INC. Dated February 3, 2023
License Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations • New York

This License Agreement (this “Agreement”) is entered into as of February 3, 2023 (the “Execution Date”) by and between Pipeline Therapeutics, Inc., a Delaware corporation (“Licensor”), on the one hand, and Janssen Pharmaceutica NV, a Belgium company (“Janssen”), on the other hand. Licensor and Janssen are referred to in this Agreement each individually as a “Party” and collectively as the “Parties.”

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations • California

This FIRST AMENDMENT to Loan and Security Agreement (this “Agreement”) is entered into as of March 15, 2021, by and between SILICON VALLEY BANK, a California corporation (“Bank”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Borrower”).

AGREEMENT FOR TERMINATION OF LEASE AND VOLUNTARY SURRENDER OF PREMISES
Agreement for Termination of Lease • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations

This Agreement for Termination of Lease and Voluntary Surrender of Premises (this “Agreement”) is made and entered into as of October 25 , 2023, by and between ARE-SD REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Tenant”), with reference to the following:

THIRD AMENDMENT TO LEASE
Lease • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations

THIS THIRD AMENDMENT TO LEASE (this “Third Amendment”) is made as of June 15, 2021, by and between ARE-SD REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

FIRST AMENDMENT TO LEASE
Lease • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations

This First Amendment to Lease (this “First Amendment”) is made as of February 16, 2018, by and between ARE-SD REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

PIPELINE THERAPEUTICS, INC. AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations • Delaware

THIS AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the “Agreement”) is entered into as of the 9th day of February, 2021, by and among PIPELINE THERAPEUTICS, INC. (f/k/a Sirocco Therapeutics, Inc.), a Delaware corporation (the “Company”), and the investors listed on Exhibit A hereto, referred to hereinafter as the “Investors” and each individually as an “Investor.”

SECOND AMENDMENT TO LEASE
Lease • March 15th, 2024 • Contineum Therapeutics, Inc. • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of April 2, 2018, by and between ARE-SO REGION NO. 44, LLC, a Delaware limited liability company (“Landlord”), and PIPELINE THERAPEUTICS, INC., a Delaware corporation (“Tenant”).

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