0001193125-11-115399 Sample Contracts

MANAGEMENT RETENTION AGREEMENT
Management Retention Agreement • April 28th, 2011 • Ap Pharma Inc /De/ • Pharmaceutical preparations • California

This Management Retention Agreement (the “Agreement”) is dated as of April 25, 2011, by and between John B. Whelan (“Employee”) and A.P. Pharma, Inc., a Delaware corporation (the “Company”). This Agreement is intended to provide Employee with certain benefits described herein upon the occurrence of specific events.

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SECURITY AGREEMENT
Patent Security Agreement • April 28th, 2011 • Ap Pharma Inc /De/ • Pharmaceutical preparations • California

This SECURITY AGREEMENT (this “Agreement”), dated as of April 24, 2011 among A.P. PHARMA, INC. and those additional entities that hereafter become parties hereto by executing the form of Supplement attached hereto as Annex 1 (“Grantor”), and TANG CAPITAL PARTNERS, LP, in its capacity as representative of the Purchasers (together with its successors, “Agent”).

SECURITIES PURCHASE AGREEMENT AMONG A.P. PHARMA, INC., TANG CAPITAL PARTNERS, LP, BAKER BROS. INVESTMENTS II, L.P., BAKER BROTHERS LIFE SCIENCES, L.P., AND 14159, L.P. DATED AS OF APRIL 24, 2011
Securities Purchase Agreement • April 28th, 2011 • Ap Pharma Inc /De/ • Pharmaceutical preparations • California

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of April 24, 2011 by and among A.P. Pharma, Inc., a Delaware corporation (the “Company”), Tang Capital Partners, LP, a Delaware limited partnership, Baker Bros. Investments II, L.P., a Delaware limited partnership, Baker Brothers Life Sciences, L.P., a Delaware limited partnership and 14159, L.P., a Delaware limited partnership (each a “Purchaser” and together the “Purchasers”). Certain terms used and not otherwise defined in the text of this Agreement are defined in Section 12 hereof.

SECOND AMENDMENT TO LEASE
Lease • April 28th, 2011 • Ap Pharma Inc /De/ • Pharmaceutical preparations

This Second Amendment to Lease (“Amendment”) is entered into as of April 1, 2011 (the “Effective Date”) by and between METROPOLITAN LIFE INSURANCE COMPANY, a New York corporation (“Landlord”), and AP PHARMA, INC., a Delaware corporation (“Tenant”), with reference to the following facts (“Recitals”):

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