0001104659-11-026863 Sample Contracts

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • May 6th, 2011 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of April , 2011, between Synergy Pharmaceuticals, Inc., a Florida corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

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SECOND AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT
Executive Employment Agreement • May 6th, 2011 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This SECOND AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”) dated May 2, 2011 by and between Synergy Pharmaceuticals,, Inc., a company incorporated under the laws of Florida (the “Company”), and Gary S. Jacob, Ph.D., an individual (the “Executive”) with reference to the following facts:

COMMON STOCK PURCHASE WARRANT SYNERGY PHARMACEUTICALS, INC.
Common Stock Purchase Warrant • May 6th, 2011 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after (the “Initial Exercise Date”) and on or prior to the close of business on the seven year anniversary of the Initial Exercise Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Synergy Pharmaceuticals, Inc., a Florida corporation (the “Company”), up to shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECOND AMENDED AND RESTATED CONSULTING AGREEMENT
Consulting Agreement • May 6th, 2011 • Synergy Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This SECOND AMENDED AND RESTATED CONSULTING AGREEMENT (the “Agreement”) is made and entered into as of the 2nd day of May 2011 by and between Gabriele M. Cerrone (“Consultant”) and Synergy Pharmaceuticals, Inc., a Florida corporation (the “Company”).

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