0000898432-05-000050 Sample Contracts

Contract
Purchase Agreement • January 28th, 2005 • Biotechnology Value Fund L P • Investment advice • New York

THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR EXEMPTION FROM REGISTRATION UNDER THE FOREGOING LAWS.

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AGREEMENT REGARDING JOINT FILING
Exhibit 1 Agreement • January 28th, 2005 • Biotechnology Value Fund L P • Investment advice

The undersigned, Biotechnology Value Fund, L.P., a Delaware limited partnership, Biotechnology Value Fund II, L.P., a Delaware limited partnership, BVF Investments, L.L.C., a Delaware limited liability company, Investment 10, L.L.C., an Illinois limited liability company, BVF Partners L.P., a Delaware limited partnership, and BVF Inc., a Delaware corporation, hereby agree and acknowledge that the information required by Schedule 13D, to which this Agreement is attached as an exhibit, is filed on behalf of each of them. The undersigned further agree that any amendments or supplements thereto shall also be filed on behalf of each of them.

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • January 28th, 2005 • Biotechnology Value Fund L P • Investment advice • New York

This SECURITIES PURCHASE AGREEMENT, dated as of January 14, 2005 (this “Agreement”), is by and between The Convertible Fund Offshore, Ltd., a corporation duly organized under the laws of the British Virgin Islands (the “Seller”); and the undersigned purchasers (“Purchasers”)

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