DATED 30 APRIL 1996 ----------------------------------------Service Agreement • August 16th, 1999 • Proteus International P L C /Fi
EXHIBIT 4.12 (ASHURST MORRIS CRISP LOGO) MANUFACTURING AGREEMENT Protherics UK Limited and Chesapeake Biological Laboratories Inc. 19 March 2003Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
AMENDMENT NO. 3 TO DISTRIBUTION AGREEMENTDistribution Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations • Tennessee
CONFIDENTIALLicense Agreement • August 16th, 1999 • Proteus International P L C /Fi
CONTENTSAgreement • July 31st, 2006 • Protherics PLC • Pharmaceutical preparations
Deposit Agreement Dated as of June 20, 1995 Amended and Restated as of September 27, 2005Deposit Agreement • December 27th, 2007 • Protherics PLC • Pharmaceutical preparations • New York
EXHIBIT 4.11 [ASHURST MORRIS CRISP LOGO] Supply Agreement Selborne Biological Services (Australia) Pty Limited and Protherics Australasia Pty Limited 21st October 2002Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations • South Australia
EXHIBIT 4.29 [ASHURST LOGO] Consultancy Agreement Protherics Plc and Chimaeron Limited and Professor Anthony Atkinson THIS DEED is made on 27 September 2004 BETWEEN: (1) PROTHERICS PLC (No. 2459087) whose registered office is at The Heath Business and...Protherics PLC • September 30th, 2004 • Pharmaceutical preparations
STUART M WALLIS -AND-Proteus International P L C /Fi • August 16th, 1999
EXHIBIT 10.5 REVENUE SHARING AGREEMENT T H I S DEED is made the 8th day of September 1998 B E T W E E N (1) PROTEUS MOLECULAR DESIGN LIMITED whose company registration number in England is 2459087 and whose registered office is at Beechfield House,...Revenue Sharing Agreement • August 16th, 1999 • Proteus International P L C /Fi
Exhibit 4.13 THIS INSTRUMENT is made by way of deed on 6 June 2006 BY: PROTHERICS PLC (No.02459087) whose registered office is at The Heath Business and Technical Park, Runcorn, Cheshire WA7 4QF (the "COMPANY") WHEREAS the Company has, pursuant to its...Protherics PLC • July 31st, 2006 • Pharmaceutical preparations • London
DE BRAUW BLACKSTONE WESTBROEK ASSET SALE AND PURCHASE AGREEMENT between COVACCINE B.V. and PROTHERICS MOLECULAR DESIGN LIMITED And PROTHERICS PLC Dated 6 June 2006And Purchase Agreement • July 31st, 2006 • Protherics PLC • Pharmaceutical preparations
ANDConsultancy Services Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
EXHIBIT 4.30 AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD DATED 1ST APRIL 2000. 22nd February 2001 Following a change, the registered address of the "Company" shall now read 8 Centre One, Old Sarum Park, Lysander Way, Salisbury,...Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
Following a change, the registered address of the "Company" shall now read 8 Centre One, Old Sarum Park, Lysander Way, Salisbury, SP4 6BU.
AMENDMENT TO AGREEMENT BETWEEN ENACT PHARMA PLC AND CHIMAERON LTD DATED 1ST APRIL 2000. 1st December 2001 The paragraph referring to Consultant's Fees shall be amended to read "The fee is at present L90,000 per annum exclusive of VAT, or such other...Agreement • September 30th, 2003 • Protherics PLC • Pharmaceutical preparations
The paragraph referring to Consultant's Fees shall be amended to read "The fee is at present L90,000 per annum exclusive of VAT, or such other rate as may be agreed from time to time payable monthly in arrears by bank credit transfer. This agreement shall be terminable by either party giving to the other not less than six months' prior written notice."
CONSULTANCY AGREEMENTConsultancy Agreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • England
This Consultancy Agreement (the “Agreement”) is effective from 1 April 2007 and is made between PROTHERICS PLC (“Protherics” or the “Company”) whose registered office is the Heath Business and Technical Park, Runcorn, Cheshire WA7 4QX (registered in England and Wales under number 02459087) and “STUART MICHAEL WALLIS of Briarwood, Nightingales Lane, Chalfont St. Giles, Buckinghamshire HP8 4SR trading as “Stuart Wallis Associates” (the “Consultant”) and replaces the consultancy agreement dated 1 September 1998 made between Therapeutic Antibodies (UK) Limited and “Stuart M Wallis” trading as “Stuart Wallis Associates” (the “Consultant”).
Executive Service AgreementService Agreement • August 5th, 2008 • Protherics PLC • Pharmaceutical preparations
EXHIBIT 4.9 (PROTHERICS LOGO) Swedish Orphan AB Dtottninggatan 98 S-11160 Stockholm Sweden 14 November 2003 Dear Sirs, Product Agreement dated January 1990 between Swedish Orphan AB (now Swedish Orphan International AB) and Therapeutic Antibodies...Protherics PLC • September 30th, 2004 • Pharmaceutical preparations
AMENDMENT NO. 1 TO THE AGREEMENT AND PLAN OF MERGER AND REORGANIZATIONThe Agreement and Plan of Merger and Reorganization • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • Utah
THIS AMENDMENT NO. 1 TO THE AGREEMENT AND PLAN OF MERGER AND REORGANIZATION, dated as of January 3, 2007 (this “Amendment”) is by and among Protherics PLC, a public limited company incorporated under the laws of England and Wales (registered number 2459087) (“PTI”), MacroMed Acquisition Corp., a Utah corporation and a direct, wholly-owned subsidiary of PTI (“PTI Merger Sub”), and MacroMed, Inc., a Utah corporation (the “Company”).
FIRST AMENDMENT TO LICENSE AGREEMENTLicense Agreement • August 5th, 2008 • Protherics PLC • Pharmaceutical preparations
This first amendment (the “Amendment”) to License Agreement is effective as of April 15, 2008 (the “Amendment Effective Date”), by on the one hand Protherics Medicines Development Limited (“Protherics”), and on the other hand, Glenveigh Pharmaceuticals, LLC, Glenveigh Research, LLC, C. David Adair, M.D., CDA Royalty Investors, LLC, and CDA Licensing Administrators, LLC (collectively, each such entity and individual referred to individually as a “Glenveigh Holder” and such entities and Dr. Adair, referred to collectively as “Glenveigh”). Protherics and Glenveigh may be referred to herein individually as a “Party” and collectively as the “Parties.”
ONCOGEL/GENEXOL RESTATED LICENSE AND SUPPLY AGREEMENT Dated: JUNE 20th , 2006License and Supply Agreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • Utah
This RESTATED LICENSE AND SUPPLY AGREEMENT (hereinafter the “Restated Agreement”) is made and entered into , 2006 (the “Restated Agreement Date”), intended to be effective retroactively to November 23, 2001, by and between SAMYANG GENEX CORPORATION (“Genex”), a Korean corporation, having its principal place of business at 263 Yeonji-dong, Chongno-gu, Seoul, Korea, and MACROMED, INC. (“MacroMed”), a Utah corporation, having its principal place of business at 9520 South State Street, Sandy, Utah 84070, U.S.A. This Restated Agreement amends, restates, and supersedes, in its entirety, that certain OncoGel/Genexol License and Supply Agreement dated November 23, 2001 (the “Original Agreement”).
LICENSE AGREEMENT AMONG PROTHERICS MEDICINES DEVELOPMENT LIMITED (“PROTHERICS”) AND GLENVEIGH PHARMACEUTICALS, LLC, GLENVEIGH RESEARCH, LLC C. DAVID ADAIR, M.D. CDA ROYALTY INVESTORS LLC and CDA LICENSING ADMINISTRATORS LLC (collectively, “GLENVEIGH”)...License Agreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • Tennessee
This License Agreement (this “Agreement”), executed as of December 7, 2006 (the “Execution Date”), is made by and among, on the one hand, Protherics Medicines Development Limited, a company incorporated in England and Wales under number 1939643, being a wholly owned subsidiary of Protherics plc, and whose registered office is at The Heath Business and Technical Park, Runcorn, Cheshire WA7 4QX, England (“Protherics”), and on the other hand, Glenveigh Pharmaceuticals, LLC, a Delaware limited liability company with its principal place of business at 2530 Meridian Parkway, Suite 300, Durham, NC 27713, Glenveigh Research, LLC, a Tennessee limited liability company with its principal place of business at 979 E. Third Street, Suite C-825, Chattanooga, TN 37403, C. David Adair, M.D., an individual physician with offices at 979 E. Third Street, Suite C-825, Chattanooga, TN 37403, CDA Royalty Investors, LLC, a Delaware limited liability company with its principal place of business at 1403 Foulk
AMENDED AND RESTATED EMPLOYMENT AGREEMENTEmployment Agreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • Tennessee
This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (“Agreement”) is entered into as of this 8th day of June, 2007, by and between Protherics Inc, (the “Company”), and Saul Komisar (“Employee”).
ContractAgreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • London
* Portions of this exhibit have been omitted pursuant to a request for confidential treatment and have been filed separately with the Commission.
APPOINTMENT AS NON-EXECUTIVE CHAIRMAN OF PROTHERICS PLCProtherics PLC • August 13th, 2007 • Pharmaceutical preparations
This letter confirms the main terms of your appointment to the above office and replaces your letter of appointment dated 1 September 1998 with effect from 1 April 2007.
PROTHERICS MOLECULAR DESIGN LIMITED and IDIS LIMITED SUPPLY AND DISTRIBUTION AGREEMENTSupply and Distribution Agreement • August 5th, 2008 • Protherics PLC • Pharmaceutical preparations • England and Wales
EXCLUSIVE LICENSE AGREEMENTExclusive License Agreement • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • California
This Exclusive License Agreement (this “Agreement”) is made as of 15th day of December, 2004 (“Effective Date”) by and between MacroMed, Inc., a Utah corporation, having its principal offices at 9520 S. State, Street, Sandy, Utah 84070 (“MacroMed”) and Diatos SA, a French corporation, having its principal offices at 166 boulevard du Montparnasse, 75014 Paris, France (“Diatos”). MacroMed and Diatos shall be referred to herein, collectively, as the “Parties,” and may be referenced individually as a “Party.”
AGREEMENT AND PLAN OF MERGER AND REORGANIZATION dated as of December 7, 2006 by and among PROTHERICS PLC, MACROMED ACQUISITION CORP. and MACROMED, INC.Agreement and Plan of Merger and Reorganization • August 13th, 2007 • Protherics PLC • Pharmaceutical preparations • Utah
THIS AGREEMENT AND PLAN OF MERGER AND REORGANIZATION, dated as of December 7, 2006 (this “Agreement”) is by and among Protherics PLC, a public limited company incorporated under the laws of England and Wales (registered number 2459087) (“PTI”), MacroMed Acquisition Corp., a Utah corporation and a direct, wholly-owned Subsidiary of PTI (“PTI Merger Sub”), and MacroMed, Inc., a Utah corporation (the “Company”).
