Arrowhead Pharmaceuticals, Inc. Sample Contracts

4,000,000 Shares Arrowhead Pharmaceuticals, Inc. UNDERWRITING AGREEMENT
Underwriting Agreement • December 6th, 2019 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • New York
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COMMON STOCK PURCHASE WARRANT ARROWHEAD RESEARCH CORPORATION
Arrowhead Research Corp • January 30th, 2013 • Services-commercial physical & biological research • California

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) and on or prior to the close of business on the fifth anniversary of the Issue Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Arrowhead Research Corporation, a Delaware corporation (the “Company”), up to shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 13th, 2012 • Arrowhead Research Corp • Services-commercial physical & biological research • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of August 10, 2012 between Arrowhead Research Corporation, a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • October 26th, 2011 • Arrowhead Research Corp • Services-commercial physical & biological research • Illinois

REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 20, 2011, by and between ARROWHEAD RESEARCH CORPORATION, a Delaware corporation, (the “Company”), and LINCOLN PARK CAPITAL FUND, LLC, an Illinois limited liability company (together with its permitted assigns, the “Buyer”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Purchase Agreement by and between the parties hereto, dated as of the date hereof (as amended, restated, supplemented or otherwise modified from time to time, the “Purchase Agreement”).

RIGHTS AGREEMENT between ARROWHEAD PHARMACEUTICALS, INC. and COMPUTERSHARE TRUST COMPANY, N.A., as Rights Agent Dated as of March 21, 2017
Rights Agreement • March 23rd, 2017 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

RIGHTS AGREEMENT, dated as of March 21, 2017 (this “Agreement”), between Arrowhead Pharmaceuticals, Inc. (f/k/a Arrowhead Research Corporation), a Delaware corporation (the “Company”), and Computershare Trust Company, N.A., a federally chartered trust company (the “Rights Agent”).

OPEN MARKET SALE AGREEMENTSM
Arrowhead Pharmaceuticals, Inc. • December 5th, 2022 • Pharmaceutical preparations • New York
OPEN MARKET SALE AGREEMENT1
Open Market Sale • December 8th, 2022 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

Arrowhead Pharmaceuticals, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stock, par value $0.001 per share (the “Common Shares”), having an aggregate offering price of up to $250,000,000 on the terms set forth in this agreement (this “Agreement”).

6,592,989 Units ARROWHEAD RESEARCH CORPORATION PLACEMENT AGENT AGREEMENT
Placement Agent Agreement • June 18th, 2010 • Arrowhead Research Corp • Services-commercial physical & biological research • New York
OFFICE LEASE
Office Lease • August 5th, 2019 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • Colorado

This Office Lease (the "Lease"), dated as of the date set forth in Section 1 of the Summary of Basic Lease Information (the "Summary"), below, is made by and between 177 COLORADO OWNER LLC, a Delaware limited liability company ("Landlord"), and ARROWHEAD PHARMACEUTICALS, INC., a Delaware corporation ("Tenant").

PURCHASE AGREEMENT
Purchase Agreement Purchase Agreement • October 26th, 2011 • Arrowhead Research Corp • Services-commercial physical & biological research • Illinois

PURCHASE AGREEMENT (the “Agreement”), dated as of October 20, 2011, by and between ARROWHEAD RESEARCH CORPORATION, a Delaware corporation (the “Company”), and LINCOLN PARK CAPITAL FUND, LLC, an Illinois limited liability company (the “Investor”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • February 7th, 2019 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

This Agreement is made pursuant to the Stock Purchase Agreement, dated as of October 3, 2018, between the Company and the Purchaser (the “Purchase Agreement”).

LEASE AGREEMENT
Lease Agreement • February 2nd, 2022 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations

THIS LEASE AGREEMENT (this “Lease”) is made this 19 day of November, 2021 (the “Effective Date”), between ARE‑SD REGION NO. 72, LLC, a Delaware limited liability company (“Landlord”), and ARROWHEAD PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 10th, 2016 • Arrowhead Pharmaceuticals, Inc. • Services-commercial physical & biological research • New York

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of August 8, 2016 (the “Effective Date”) by and among Arrowhead Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and each of those persons and entities, severally and not jointly, listed as a Purchaser on the Schedule of Purchasers attached as Schedule I hereto (each a “Purchaser” and together the “Purchasers”). Certain terms used and not otherwise defined in the text of this Agreement are defined in Section 11 hereof.

UNIDYM, INC. SUBSCRIPTION AGREEMENT SERIES C-1 PREFERRED STOCK
Subscription Agreement • August 10th, 2009 • Arrowhead Research Corp • Services-commercial physical & biological research • California

THIS SUBSCRIPTION AGREEMENT (this “Agreement”) is made as of the last date indicated on the signature pages hereto between Unidym, Inc., a Delaware corporation (the “Company”), and the undersigned investor party hereto (“Investor”).

SECOND AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • December 22nd, 2009 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

This Second Amended and Restated Investors’ Rights Agreement (the “Agreement”) is made as of the September 30, 2009, by and between Unidym, Inc., a Delaware corporation (the “Company”), each of the investors listed on Schedule A hereto (each of which is referred to in this Agreement as an “Investor”) and each of the stockholders listed on Schedule B hereto (each of which is referred to in this Agreement as a “Stockholder”).

STRICTLY CONFIDENTIAL Arrowhead Research Corporation
Letter Agreement • January 30th, 2013 • Arrowhead Research Corp • Services-commercial physical & biological research • New York
SERIES B PREFERRED STOCK PURCHASE AGREEMENT
Preferred Stock Purchase Agreement • July 25th, 2008 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

THIS SERIES B PREFERRED STOCK PURCHASE AGREEMENT is made as of the 23rd day of July, 2008 by and among Nanotope, Inc., a Delaware corporation (the “Company”), Arrowhead Research Corporation, a Delaware corporation, and the investors listed on Exhibit A attached to this Agreement (each an “Initial Purchaser”) and the investors listed on Exhibit A attached to this Agreement (each a “Subsequent Purchasers” and together with the Initial Purchasers, the “Purchasers”).

SEVERANCE AGREEMENT
Severance Agreement • May 30th, 2007 • Arrowhead Research Corp • Services-commercial physical & biological research • California

This SEVERANCE AGREEMENT (the “Agreement”) is made and entered into effective May 24, 2007, by and between Arrowhead Research Corporation, a Delaware corporation (the “Company”), and R. Bruce Stewart, an individual (the “Executive”).

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ARROWHEAD RESEARCH CORPORATION SUBSCRIPTION AGREEMENT
Subscription Agreement • December 22nd, 2009 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware
SUBSCRIPTION AGREEMENT
Subscription Agreement • October 26th, 2011 • Arrowhead Research Corp • Services-commercial physical & biological research • California

This Subscription Agreement (this “Agreement”) is made and entered into as of October 21, 2011 by and among Arrowhead Research Corporation, a Delaware corporation (the “Company”), and the undersigned hereto (each a “Purchaser” and together the “Purchasers”). Certain terms used and not otherwise defined in the text of this Agreement are defined in Section 9 hereof.

INVESTOR SUBSCRIPTION AGREEMENT
Investor Subscription Agreement • January 30th, 2013 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

This Investor Subscription Agreement (this “Agreement”) is entered into on January , 2013 by and between Arrowhead Research Corporation, a Delaware corporation (the “Company”), and the Purchaser identified on the signature page hereto (the “Purchaser”).

Royalty Purchase Agreement By and Between Arrowhead Pharmaceuticals, Inc. and Royalty Pharma Investments 2019 ICAV Dated as of November 9, 2022
Royalty Purchase Agreement • February 6th, 2023 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • New York

This ROYALTY PURCHASE AGREEMENT, dated as of November 9, 2022 (this “Agreement”), is made and entered into by and between Arrowhead Pharmaceuticals, Inc., a Delaware corporation (the “Seller”), on the one hand, and Royalty Pharma Investments 2019 ICAV, an Irish collective asset-management vehicle (the “Buyer”), on the other hand. Unless otherwise defined in this Agreement, capitalized terms have the meanings ascribed to them in Section 1 below.

ARROWHEAD PHARMACEUTICALS, INC. RESTRICTED STOCK UNIT AGREEMENT (EMPLOYEES)
Restricted Stock Unit Agreement • December 22nd, 2021 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations

This agreement (this “Agreement”) evidences an award (the “Award”) consisting of, in aggregate, the number of restricted stock units set forth in the table above (the “Restricted Stock Units” or “RSUs”) granted by Arrowhead Pharmaceuticals, Inc. (the “Company”) to the individual named above (the “Grantee”). The Award has been granted as an “inducement” award under NASDAQ Marketplace Rules outside of the Company’s existing equity compensation plans. However, the Award will be governed in all respects as if issued under the Company’s 2021 Incentive Plan (the “Plan”), as currently in effect and as may be amended hereafter from time to time, the terms of which are incorporated herein by reference.

STOCK PURCHASE AGREEMENT
Stock Purchase Agreement • February 7th, 2019 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

THIS STOCK PURCHASE AGREEMENT (this “Agreement”), dated as of October 3, 2018, (the “Effective Date”) by and between Johnson & Johnson Innovation-JJDC, Inc. (the “Investor”), a New Jersey corporation with its principal place of business at 410 George Street, New Brunswick, New Jersey 08901, and Arrowhead Pharmaceuticals, Inc. (the “Company”), a Delaware corporation, with its principal place of business at 225 S. Lake Avenue, Suite 1050, Pasadena, California 91101.

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 10th, 2013 • Arrowhead Research Corp • Services-commercial physical & biological research • New York

This SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of October 8, 2013 by and among Arrowhead Research Corporation, a Delaware corporation (the “Company”), and the purchasers listed on Schedule I hereto (each a “Purchaser” and together the “Purchasers”). Certain terms used and not otherwise defined in the text of this Agreement are defined in Section 11 hereof.

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • December 22nd, 2009 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made and entered into as of this 11th day of December, 2009 by and among Arrowhead Research Corporation, a Delaware corporation (the “Company”) and the purchasers of the Company’s Units (as defined below) listed on Exhibit A hereto, as may be amended from time to time (the “Investors”).

ASSET PURCHASE AGREEMENT
Asset Purchase Agreement • February 11th, 2010 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

This Asset Purchase Agreement (this “Agreement”) is entered into as of November 13, 2009, by and between Tego Biosciences, Inc., a Delaware corporation with offices at 201 S. Lake Avenue, Suite 703, Pasadena, CA 91101 (“Tego”), and Luna Innovations Incorporated, a Delaware corporation and Debtor and Debtor in Possession (“Luna”) under Case No. 09-71811 (the “Case”) in the United States Bankruptcy Court for the Western District of Virginia (the “Bankruptcy Court”), with offices at 1 Riverside Circle, Suite 400, Roanoke, VA 24016; and with reference to the following facts:

CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[**]”. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING...
Stock and Asset Purchase Agreement • December 20th, 2011 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

AGREEMENT (this “Agreement”) dated as of October 21, 2011 by and among Arrowhead Research Corporation, a Delaware corporation (“Buyer”), Hoffmann-La Roche Inc., a New Jersey corporation (“Roche Nutley”), and F. Hoffmann-La Roche Ltd, a Swiss corporation (“Roche Basel” and, together with Roche Nutley, “Sellers”).

SUBSCRIPTION AGREEMENT
Subscription Agreement • June 18th, 2010 • Arrowhead Research Corp • Services-commercial physical & biological research • New York

Please confirm that the foregoing correctly sets forth the agreement between us by signing in the space provided below for that purpose.

CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[**]”. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING...
Collaboration Agreement • December 20th, 2011 • Arrowhead Research Corp • Services-commercial physical & biological research • Delaware

This Collaboration Agreement (this “Agreement”) is entered into as of the 29th day of October 2009 (the “Effective Date”), by and among F. Hoffmann-La Roche Ltd, a Swiss corporation (“Roche Basel”), having a place of business at Grenzacherstrasse 124, CH-4070 Basel, Switzerland, and Hoffmann-La Roche Inc., a New Jersey corporation (“Roche Nutley”), having a place of business at 340 Kingsland Street, Nutley, New Jersey 07110, U.S.A. (Roche Basel and Roche Nutley, collectively, “Roche”), and Alnylam Pharmaceuticals, Inc., a Delaware corporation, having a place of business at 300 Third Street, 3rd Floor, Cambridge, Massachusetts 02142, U.S.A. (“Alnylam”).

FIRST AMENDMENT TO OFFICE LEASE
Office Lease • February 4th, 2021 • Arrowhead Pharmaceuticals, Inc. • Pharmaceutical preparations

This FIRST AMENMENT TO OFFICE LEASE (‘‘First Amendment’’) is made and entered into on the 23rd day of October, 2020 (the ‘‘Effective Date’’), by and between 177 COLORADO OWNER LLC, a Delaware limited liability company (‘‘Landlord’’), and ARROWHEAD PHARMACEUTICALS, INC., a Delaware corporation (‘‘Tenant’’).

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