Hillstream BioPharma Inc. Sample Contracts

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Security Agreement • June 20th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

UNDERWRITING AGREEMENT between HILLSTREAM BIOPHARMA, INC. and THINKEQUITY LLC as Representative of the Several Underwriters HILLSTREAM BIOPHARMA, INC.
Underwriting Agreement • May 1st, 2023 • Hillstream BioPharma Inc. • Pharmaceutical preparations • New York

The undersigned, Hillstream BioPharma, Inc., a corporation formed under the laws of the State of Delaware (collectively with its subsidiaries and affiliates, including, without limitation, all entities disclosed or described in the Registration Statement (as hereinafter defined) as being subsidiaries or affiliates of Hillstream BioPharma, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with ThinkEquity LLC (hereinafter referred to as “you” (including its correlatives) or the “Representative”) and with the other underwriters named on Schedule 1 hereto for which the Representative is acting as representative (the Representative and such other underwriters being collectively called the “Underwriters” or, individually, an “Underwriter”) as follows:

HILLSTREAM BIOPHARMA, INC. INDEMNIFICATION AGREEMENT
Indemnification Agreement • September 27th, 2021 • Hillstream BioPharma Inc. • Pharmaceutical preparations • Delaware

This INDEMNIFICATION AGREEMENT (“Agreement”) is made as of [ ], 2021 by and between Hillstream BioPharma, Inc., a Delaware corporation (the “Company”), and [ ] (“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Company and Indemnitee covering the subject matter of this Agreement.

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Warrant Agreement • December 6th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, _________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to _______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

COMMON STOCK PURCHASE WARRANT THARIMMUNE, Inc.
Common Stock Purchase Warrant • June 20th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, __________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, beginning six months after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the five (5) year anniversary of the Initial Exercise Date (the “Termination Date”), but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to ______ shares of common stock, par value $0.0001 per share (the “Common Stock”) (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

AT THE MARKET OFFERING AGREEMENT
At the Market Offering Agreement • June 7th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations • New York

Tharimmune, Inc., a corporation organized under the laws of Delaware (the “Company”), confirms its agreement (this “Agreement”) with Rodman & Renshaw LLC (the “Manager”) as follows:

FORM OF REPRESENTATIVE’S WARRANT AGREEMENT Tharimmune, Inc.
Representative’s Warrant Agreement • November 17th, 2023 • Tharimmune, Inc. • Pharmaceutical preparations

THIS WARRANT TO PURCHASE COMMON STOCK (the “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after [__], 2023 (the “Initial Exercise Date”) and, in accordance with FINRA Rule 5110(g)(8)(A), prior to at 5:00 p.m. (New York time) on the date that is five (5) years following the Effective Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc. (formerly Hillstream BioPharma, Inc.), a Delaware corporation (the “Company”), up to ______ shares of common stock, par value $0.0001 per share (the “Common Stock”), of the Company (the “Warrant Shares”), as subject to adjustment hereunder. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • June 20th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of June 13, 2025 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • June 20th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of June 18, 2024 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

UNDERWRITING AGREEMENT between THARIMMUNE, INC. and THINKEQUITY LLC as Representative of the Several Underwriters THARIMMUNE, INC.
Underwriting Agreement • November 17th, 2023 • Tharimmune, Inc. • Pharmaceutical preparations • New York

The undersigned, Tharimmune, Inc. (formerly Hillstream BioPharma, Inc.), a corporation formed under the laws of the State of Delaware (collectively with its subsidiaries and affiliates, including, without limitation, all entities disclosed or described in the Registration Statement (as hereinafter defined) as being subsidiaries or affiliates of Tharimmune, Inc., the “Company”), hereby confirms its agreement (this “Agreement”) with ThinkEquity LLC (hereinafter referred to as “you” (including its correlatives) or the “Representative”) and with the other underwriters named on Schedule 1 hereto for which the Representative is acting as representative (the Representative and such other underwriters being collectively called the “Underwriters” or, individually, an “Underwriter”) as follows:

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • December 6th, 2024 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of December 5, 2024 (the “Effective Date”), between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

SERIES A COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Warrant Agreement • June 20th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS SERIES A COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, beginning six months after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the five (5) year anniversary of the Initial Exercise Date (the “Termination Date”), but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to ______ shares of common stock, par value $0.0001 per share (the “Common Stock”) (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Security Agreement • July 31st, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to _______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • July 28th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of July 23, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Security Agreement • July 28th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ___________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to _________ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • July 31st, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of July 25, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

AMENDED and RESTATED MILBY EMPLOYMENT AGREEMENT
Employment Agreement • July 11th, 2023 • Hillstream BioPharma Inc. • Pharmaceutical preparations • Delaware

THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of July 6, 2023 (the “Effective Date”) by and between Hillstream BioPharma Inc., a Delaware corporation with principal executive offices at 245 Main Street, Suite 204, Chester, New Jersey 07930 (“Company”), and Randy D. Milby, residing at [ ] (“Executive”). Each of Company and Executive is referred to herein as a “Party” and together they are referred to as the “Parties.”

EMPLOYMENT AGREEMENT
Employment Agreement • November 6th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

This Employment Agreement (this “Agreement”) is made as of November __, 2025 and is entered into by and between Tharimmune, Inc. (the “Company”) and Mark Wendland (“Employee”) (collectively with the Company, the “Parties”; each of the Parties referred to individually as a “Party”).

Contract
Security Agreement • November 5th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS INSTRUMENT CANNOT BE TRANSFERRED. NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS. THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN ACCOUNT WITH A REGISTERED BROKER DEALER OR OTHER LOAN WITH A FINANCIAL INSTITUTION THAT IS AN “ACCREDITED INVESTOR” AS DEFINED IN RULE 501(a) UNDER THE SECURITIES ACT OR OTHER LOAN SECURED BY SUCH SECURITIES.

PATENT LICENSE AGREEMENT
Patent License Agreement • November 7th, 2023 • Tharimmune, Inc. • Pharmaceutical preparations • New York

THIS PATENT LICENSE AGREEMENT (this “Agreement”) is entered into as of the 3rd day of November, 2023, (the “Effective Date”) by and between Avior Inc. dba Avior Bio, a North Carolina corporation (the “Licensor”) and Tharimmune, Inc., a Delaware corporation (the “Licensee”). Licensor and Licensee may individually be referred to as a “Party” and collectively as the “Parties.”

COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Common Stock Purchase Warrant • July 31st, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ________________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, beginning six months after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the seven (7) year anniversary of the Initial Exercise Date (the “Termination Date”), but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to _________ shares of common stock, par value $0.0001 per share (the “Common Stock”) (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Pre-Funded Warrant Agreement • June 20th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, _________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to _______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SUBSCRIPTION AGREEMENT
Subscription Agreement • November 5th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

This SUBSCRIPTION AGREEMENT (this “Subscription Agreement”) is entered into on November 3, 2025, by and among Tharimmune, Inc., a Delaware corporation (the “Issuer”), and the undersigned investors (collectively, the “Subscribers” and each a “Subscriber”).

LOPRIORE (V) EMPLOYMENT AGREEMENT
Employment Agreement • August 14th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • Delaware

THIS EMPLOYMENT AGREEMENT (this “Agreement”) is made as of June 11, 2025 (the “Effective Date”) by and between Tharimmune Inc., a Delaware corporation with principal executive offices at 1200 Route 22 EastBridgewayer, New Jersey 08807 (“Company”), and Vincent Lopriore, residing at 21 Bruce Road Red Bank,NJ 07701 (“Executive”). Each of Company and Executive is referred to herein as a “Party” and together they are referred to as the “Parties.”

PRE-FUNDED COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Pre-Funded Warrant Agreement • November 5th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

FIRST AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT
Employment Agreement • September 27th, 2021 • Hillstream BioPharma Inc. • Pharmaceutical preparations • New Jersey

This First Amendment (the “Amendment”) to the Amended and Restated Milby Employment Agreement is dated as September 24, 2021 and is entered into by and between Hillstream BioPharma, Inc., a Delaware corporation (the “Corporation”) and Randy D. Milby (the “Executive”). All capitalized terms used herein but not otherwise defined shall have the meanings set forth in the Employment Agreement (as defined herein).

THARIMMUNE, INC. SALES AGREEMENT
Sales Agreement • November 7th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York

Tharimmune, Inc., a Delaware corporation (the “Company”), confirms its agreement (this “Agreement”) with Clear Street LLC (“Clear Street”) and President Street Global, LLC (“PSG”) (collectively, the “Sales Agents” and each, a “Sales Agent”), as follows:

August 26, 2025 Tharimmune, Inc.
Placement Agent Agreement • August 26th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York
July 23, 2025 Tharimmune, Inc.
Placement Agent Agreement • July 28th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York
COMMON STOCK PURCHASE WARRANT THARIMMUNE, INC.
Common Stock Purchase Warrant • July 28th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ______________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, beginning six months after the date hereof (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the five (5) year anniversary of the Initial Exercise Date (the “Termination Date”), but not thereafter, to subscribe for and purchase from Tharimmune, Inc., a Delaware corporation (the “Company”), up to ________ shares of common stock, par value $0.0001 per share (the “Common Stock”) (as subject to adjustment hereunder, the “Warrant Shares”). The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

STRATEGIC ADVISORY AGREEMENT
Strategic Advisory Agreement • November 5th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • Delaware

This Strategic Advisory Agreement (this “Agreement”) is entered into as of [●] 2025 (the “Effective Date”) by and between Tharimmune, Inc. (the “Company”), and DRW Canton Investments LLC, as the lead advisor (the “Lead Advisor” and together with the Company, being the “Parties” and each, a “Party”) on behalf of itself and such other advisors as the Lead Advisor will designate on Schedule A hereto (each, an “Advisor” and collectively, the “Advisors” and the Advisors).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • August 26th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of August 26, 2025, between Tharimmune, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

THARIMMUNE, INC. INDEMNIFICATION AGREEMENT
Indemnification Agreement • November 6th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations • Delaware

This INDEMNIFICATION AGREEMENT (“Agreement”) is made as of [ ], 2025 by and between Tharimmune, Inc., a Delaware corporation (the “Company”), and [ ] (“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Company and Indemnitee covering the subject matter of this Agreement.

LOCK-UP AGREEMENT
Lock-Up Agreement • November 5th, 2025 • Tharimmune, Inc. • Pharmaceutical preparations
RESEARCH AND DEVELOPMENT COLLABORATION AND LICENSE AGREEMENT
Research and Development Collaboration and License Agreement • July 11th, 2023 • Hillstream BioPharma Inc. • Pharmaceutical preparations • New York

This Research and Development Collaboration and License Agreement (the “Agreement”) is entered into as of July 5, 2023 (the “Effective Date”) by and between Applied Biomedical Science Institute (ABS Institute), a 501(c)(3) non-profit organization, having a place of business at 11011 Via Frontera, Building D, San Diego, CA 92127 (“ABSI”), and Hillstream BioPharma Inc., a Delaware corporation having an address at 1200 Route 22 East, Suite 2000, Bridgewater, NJ 08807 (“HSB”). HSB and ABSI may be referred to herein individually as a “Party” or collectively as the “Parties”.