Common use of Stress Clause in Contracts

Stress. Although no clear definition of stress exists38, it has been linked to a whole range of diseases including multiple sclerosis39, asthma40 and risk factors for cardiovascular disease.41 In migraine, both mental and physical stressors are frequently reported as trigger factor. In retrospective questionnaire studies between 30.5% and 81.8% of patients reported psychosocial stressors as trigger factor, whereas between 15.5% and 43.1% of patients identified physical stressors as possible trigger factor (Table 2). Also prospective studies using diaries suggest a positive association between mental stress and migraine.42,43 However, this seemingly apparent association between stress and migraine is difficult to replicate in observational and experimental studies using biological stress parameters such as cortisol and cardiovascular parameters. In experimental studies no difference was found in cardiovascular response between the migraine attack and the inter-ictal state.44,45 Table 2 Potential trigger factors for migraine. Trigger factor Response rate* Range (%) Food products24-30,119 Various food items 10 – 36 Missing a meal 0.9 – 55.8 Chocolate 0 – 22.5 Wine 1.4 Alcohol 20 Dairy products 18.5 Caffeine (withdrawal) 6.4 Atmospheric24-29,120 Weather changes 6.9 – 52.3 Sunlight exposure 4.2 – 38 Altitude/ hypoxia Chinook winds Smoking 2 – 26 Stress24-30,121 Psychosocial 30.5 – 81.8 Physical 15.5 – 43.1 Vacation and travel 8 – 54.6 Female Hormones24-30,122 Menstruation 20.7 – 53.5 Pharmacological Nitroglycerin55,56,78,116,123-129 20 -83% Sildenafil58 83 Dipyridamole130 50 Histamine64 50 M-chlorophenylpiperazine59 Calcitonin gene related peptide61 53 33.3 Acetazolamide65 Prostaglandine E168 Not tested in RCT Not tested in RCT Reserpine69 Not tested in RCT Calcineurin inhibitors70 Not tested in RCT Polidocanol foam71 Not tested in RCT Other Sleep (lack or excess) 72 31 – 52.4 Visual stimulation73 Cerebral angiography72 Sexual activity74 0 – 11 Use of personal computer24 6.6 *Response rate are based on findings in questionnaire studies, prospective diary studies or experimental provocation studies. General introduction regel 1 regel 2 regel 3 regel 4 regel 5 regel 6 regel 7 regel 8 regel 9 regel 10 regel 11 regel 12 regel 13 regel 14 regel 15 regel 16 regel 17 regel 18 regel 19 regel 20 regel 21 regel 22 regel 23 regel 24 regel 25 regel 26 regel 27 regel 28 regel 29 regel 30 regel 31 regel 32 regel 33 regel 34 regel 35 regel 36 regel 37 regel 38 regel 39