Common use of PSA Clause in Contracts

PSA. PSA (prostate-specific antigen) is a tumor-associated antigen expressed in prostate cancer and normal prostate tissue. PSA is also expressed in some other carcinomas. The LTIB has developed a PSA agonist construct, which is a modified form of the PSA gene to make it more immunogenic. The PROSTVAC construct contains the entire PSA gene with the PSA agonist epitope. PROSTVAC (also called Investigational Agent): PROSTVAC consists of rV-PSA/TRICOM and rF-PSA/TRICOM, which are used in a prime and boost vaccine strategy. The PSA gene contains the agonist epitope. rF-GM-CSF: rF-GM-CSF is a recombinant fowlpox expressing the human GM-CSF (granulocyte macrophage colony stimulating factor) gene. It has been demonstrated in preclinical studies to enhance the recruitment of dendritic cells to regional nodes of the vaccine site.