Common use of Permitted Uses of Vendor Property Clause in Contracts

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional Study. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional Study. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and & Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor. ; or Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGEPAGE [Name of Non-Interventional Study and Sponsor Protocol Reference Number] [Name of Principal Investigator: [*]]

Permitted Uses of Vendor Property. The Participating Organisation Trial Site will use Vendor Property only for purposes of this Non-Interventional StudyClinical Investigation. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Investigation at the Investigator Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Investigation at the Participating OrganisationTrial Site, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS TRIAL SITES IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Investigation Participant is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation Trial Site in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation Trial Site shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating OrganisationTrial Site’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation Trial Site be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation Trial Site shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY NOT AVAILABLE FOR TRIAL SITES IN SCOTLAND ENGLAND OR WALESNORTHERN IRELAND] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation Trial Site pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation Trial Site is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor Appendix 9 – Authority to Defer Registration of the Clinical Investigation under Clause 4.6.1 FINAL PAGE [DELETE IF NOT APPLICABLEName of Clinical Investigation and Sponsor Clinical Investigation Plan Reference Number] FINAL PAGE[Name of Principal Investigator: [*]]

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional Study. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/Sponsor / CRO Equipment and Sponsor/Sponsor / CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR ALL PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND, AND PARTICIPATING ORGANISATIONS IN SCOTLAND OR WALES WHICH ARE NHS PRIMARY CARE INDEPENDENT CONTRACTORS] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] [or] [Vendor Property] except to the extent that such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES PARTICIPATING ORGANISATIONS IN SCOTLAND OR WALESWALES WHICH ARE NOT NHS PRIMARY CARE INDEPENDENT CONTRACTORS] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Non-Interventional Study Related Duties and Functions to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 8 – Sponsor’s Clinical Trial Related Duties and Functions Under ICH-GCP to be Performed by CRO Appendix 7 9 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] 5 The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the State Claims Agency’s Clinical Trial Indemnity. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 Clauses 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE.

Permitted Uses of Vendor Property. The Participating Organisation Trial Site will use Vendor Property only for purposes of this Non-Interventional StudyClinical Investigation. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Investigation at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Investigation at the Participating OrganisationTrial Site, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Investigation Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation Trial Site in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation Trial Site shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating OrganisationTrial Site’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation Trial Site be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation Trial Site shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation Trial Site pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation Trial Site is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] Appendix 9 – Authority to Defer Registration of the Clinical Investigation under Clause 4.6.1 FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation Trial Site will use Vendor Property only for purposes of this Non-Interventional StudyClinical Investigation. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Investigation at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Investigation at the Participating OrganisationTrial Site, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Investigation Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation Trial Site in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation Trial Site shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating OrganisationTrial Site’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation Trial Site be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation Trial Site shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALESOption only applicable in Scotland or Wales] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation Trial Site pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation Trial Site is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] Appendix 9 – Sponsor’s Clinical Investigation Related Duties and Functions to be Performed by CRO Appendix 10 – Authority to Defer Registration of the Clinical Investigation under Clause 4.6.1 FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation Trial Site will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Investigator Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating OrganisationTrial Site, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS TRIAL SITES IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation Trial Site in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation Trial Site shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating OrganisationTrial Site’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation Trial Site be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation Trial Site shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALESWALES WHERE THE SPONSOR HAS AN MIA] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation Trial Site pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation Trial Site is constituted. Appendix 6 8 – Sponsor’s Clinical Trial Related Duties and Functions Under ICH-GCP to be Performed by CRO Appendix 7 9 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] 5 The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the State Claims Agency’s Clinical Trial Indemnity. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions Under ICH-GCP to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGESponsor

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 clauses 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 clauses 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 8 – Sponsor’s Clinical Trial Related Duties and Functions Under ICH-GCP to be Performed by CRO Appendix 7 9 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Equipment and Sponsor/CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 clauses 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Equipment], [Sponsor/CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Equipment], [Sponsor/CRO Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Equipment], [Sponsor/CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 8 – Sponsor’s Clinical Trial Related Duties and Functions Under ICH-GCP to be Performed by CRO Appendix 7 9 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGEPAGE Information Classification: General

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional StudyClinical Trial. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Trial at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Trial at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor; or a personal injury to a Clinical Trial Subject is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 clauses 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES IN SCOTLAND OR WALES] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGEPAGE Information Classification: General

Permitted Uses of Vendor Property. The Participating Organisation Trial Site will use Vendor Property only for purposes of this Non-Interventional StudyClinical Investigation. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study Clinical Investigation at the Investigator Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/Sponsor / CRO Equipment and Sponsor/Sponsor / CRO Resources and Vendor Property are and remain for the duration of the Non-Interventional Study Clinical Investigation at the Participating OrganisationTrial Site, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR PARTICIPATING ORGANISATIONS TRIAL SITES IN ENGLAND OR NORTHERN IRELAND] The Sponsor and CRO have no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] [or] [Vendor Property] except to the extent that that: such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO or the Vendor; or a personal injury to a Clinical Investigation Participant is one covered by the indemnity detailed in Appendix 3 of this Agreement. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation Trial Site in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation Trial Site shall be liable for any damage, loss or destruction of the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Material] [or] [Vendor Property] caused by the Participating OrganisationTrial Site’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation Trial Site be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation Trial Site shall not insure the [Sponsor/Sponsor / CRO Equipment], [Sponsor/Sponsor / CRO Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY NOT AVAILABLE FOR TRIAL SITES IN SCOTLAND ENGLAND OR WALESNORTHERN IRELAND] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation Trial Site pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation Trial Site is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 8 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] Appendix 9 – Sponsor’s Clinical Investigation Related Duties and Functions to be Performed by CRO Appendix 10 – Authority to Defer Registration of the Clinical Investigation under Clause 4.6.1 FINAL PAGE

Permitted Uses of Vendor Property. The Participating Organisation will use Vendor Property only for purposes of this Non-Interventional Study. [Alternatively, specify permitted uses.] Disposition of Vendor Property The Vendor will determine the disposition of Vendor Property after completion of the Non-Interventional Study at the Site. Ownership, Responsibilities, and Liability Ownership: Sponsor/CRO Sponsor Equipment and Sponsor/CRO Sponsor Resources and Vendor Property are and remain for the duration of the Non-Interventional Study at the Participating Organisation, the property of Sponsor, the CRO, the Vendor or the licensor, as the case may be. Liability: Equipment and Resources Only. Alternative #1 – indemnity provided by this Appendix 7 [N.B. THIS OPTION MUST BE SELECTED FOR ALL PARTICIPATING ORGANISATIONS IN ENGLAND OR NORTHERN IRELAND, AND PARTICIPATING ORGANISATIONS IN SCOTLAND OR WALES WHICH ARE NHS PRIMARY CARE INDEPENDENT CONTRACTORS] The Sponsor and CRO have has no liability for damages of any sort, including personal injury or property damage resulting from the use of [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [or] [Vendor Property] except to the extent that such damages were caused by the wilful misconduct, negligent acts or omissions of Sponsor, the CRO Sponsor or the Vendor. Sponsor or CRO shall be responsible for organising and ensuring payment for all costs associated with the routine maintenance of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] [and] [Vendor Property] and will replace the same at no cost to the Participating Organisation in the event replacement of the foregoing is deemed required as a result of equipment failure or routine maintenance. Subject to Clause 5.5 5.4 of the Agreement, the Participating Organisation shall be liable for any damage, loss or destruction of the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Resources] or [Vendor Property] and for any losses attributable to the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] [or] [Vendor Property] caused by the Participating Organisation’s wilful misconduct, negligent acts or omissions. Under no circumstances shall the Participating Organisation be liable for any damage caused as a result of using the equipment per instructions or due to normal wear and tear. To avoid doubt, the Participating Organisation shall not insure the [Sponsor/CRO Sponsor Equipment], [Sponsor/CRO Sponsor Material] or [Vendor Property]. Alternative #2 – Equipment is supplied under an MIA [N.B. THIS OPTION IS ONLY AVAILABLE FOR TRIAL SITES PARTICIPATING ORGANISATIONS IN SCOTLAND OR WALESWALES WHICH ARE NOT NHS PRIMARY CARE INDEPENDENT CONTRACTORS] The [Sponsor] [CRO] [Vendor] is providing the [Sponsor Equipment] [CRO Equipment] [Vendor Property] to the Participating Organisation pursuant to the terms of an MIA. The MIA that shall apply to the provided [Sponsor Equipment] [CRO Equipment] [Vendor Property] is the MIA applicable to the place where the Participating Organisation is constituted. Appendix 6 – Sponsor’s Clinical Trial Related Duties and Functions to be Performed by CRO Appendix 7 – Formal Delegation of Authority to a Corporate Affiliate to Contractually Bind Sponsor [DELETE IF NOT APPLICABLE] FINAL PAGEPAGE [Name of Non-Interventional Study and Sponsor Protocol Reference Number] [Name of Principal Investigator: [*]]