Mice lacking GPR37L1 Sample Clauses

Mice lacking GPR37L1 but not GPR37, are more susceptible to Flurothyl induced seizure Given that the most dramatic differences in the 6 Hz paradigm were observed with the homozygous knockout mice, we next compared susceptibility to flurothyl-induced seizures in homozygous knockout mice and WT littermates. Gpr37L1-/- and DKO mice exhibited significantly decreased latencies to both the first myoclonic jerk (MJ) (Figure 2-13A) and generalized tonic-clonic seizure (GTCS) (Figure 2-13B). In contrast, Gpr37-/- mice exhibited latencies comparable to WT littermates at each seizure event.