Common use of Initial Steps Clause in Contracts

Initial Steps. FOR TARGET IDENTIFICATION/VALIDATION (SEE FLOWCHART IN APPENDIX K) It is important to recognize that once a protein target has been identified that binds to a confirmed peptide hit, by virtue of the functional screen that produced the peptide hit the functional relationship of the target protein to the pathway of interest is defined for that particular cell type. False positives only arise if the peptide hit binds to additional proteins not related to the functional pathway altered by the peptide hit. Below is a protocol to discriminate false positives from pathway specific peptide/protein target pairs. [ * ] Some or all of the above methods can be employed to confirm that a peptide/protein pair, identified in the initial screen functions. It will be the task of the joint scientific board from Rigel and ▇▇▇▇▇▇▇ to determine which assays are necessary to sufficiently define a functional peptide/protein pair for the next phase of development, specifically small molecular weight compound screening.