Common use of Dose-Response Evaluation Clause in Contracts

Dose-Response Evaluation. Dose-response evaluation is the process of determining the relationship between the dose of an identified hazard and occurrence of adverse health (cancer, birth defects, etc.) within an exposed population. A dose-response evaluation is an integral step in the establishment of regulatory limits and guidelines by regulatory agencies which provide commonly accepted or allowable safe levels of exposure to the identified hazards, thus establishing exposure limits. Most existing data on dose-response is taken from animal studies and theoretical estimations of what might occur in humans. Humans are typically exposed to significantly lower contaminate concentrations than those experienced by test animals, therefore, mathematical models are incorporated to evaluate human response to contaminants at a dose far below that tested in animals. Detailed results of the dose-response evaluation are provided in Section 3.0 of Appendix II.