Common use of Collaboration Programs Clause in Contracts

Collaboration Programs. Subject to and in accordance with the terms of this Agreement, Ionis and Biogen will be responsible for conducting three programs to discover, Develop, Manufacture and Commercialize Products (each, a “Collaboration Program”), each to be focused on a different Collaboration Target, pursuant to which: 1.2.1. Ionis will use its Commercially Reasonable Efforts to (a) conduct drug discovery activities including drug screening, identification, characterization, optimization and other necessary activities according to the applicable Collaboration Program Research Plans to achieve Target Sanction status, (b) identify a Development Candidate for the applicable Collaboration Program, and (c) conduct drug development activities for each Development Candidate through completion of the first PoC Trial under a Collaboration Program in accordance with the applicable Development Plan; provided that Ionis will not be required to commence work on more than [***] Collaboration Programs in any rolling [***] month period; and 1.2.2. following the License Effective Date with respect to each Collaboration Program, Biogen will use its Commercially Reasonable Efforts to Develop, Manufacture and Commercialize at least one Product from each such Collaboration Program for which Biogen has exercised an Option in accordance with this Agreement.

Collaboration Programs. Subject to and in accordance with the terms of this Agreement, Ionis Isis and Biogen Idec will be responsible for conducting three programs to discoverDiscover, Develop, Manufacture and Commercialize Products (each, a “Collaboration Program”), each to be focused on a different Collaboration Target, pursuant to which: 1.2.1. Ionis Isis will use its Commercially Reasonable Efforts to (ai) conduct drug discovery activities including drug screening, identification, characterization, optimization and other necessary activities according to the applicable Collaboration Program Research Plans to achieve Target Sanction status, (bii) identify a Development Candidate for the applicable Collaboration Program, and (ciii) conduct drug development activities for each Development Candidate through completion of the first PoC Trial under a Collaboration Program in accordance with the applicable Development Plan; provided that Ionis Isis will not be required to commence work on more than [***] Collaboration Programs in any rolling [***] month period; and 1.2.2. following the License Effective Date with respect to each Collaboration ProgramOption exercise, Biogen Idec will use its Commercially Reasonable Efforts to Develop, Manufacture and Commercialize at least one Product from each such Collaboration Program for which Biogen Idec has exercised an Option in accordance with this Agreement.