Common use of Changes in biotransformation Clause in Contracts

Changes in biotransformation. Ap- p r op r i a t e q u a li t a t ive a n d q u a n t i t a t ive a ss a y m e t h odolog y s h a ll be u sed t o co m p a r e t h e co m posi t io n of r a dio- a c t ive co m po un ds i n exc r e t a f r o m r a t s r eceivi n g a s i n gle o r a l dose ( G r o u ps B a n d C) wi t h t h ose i n t h e exc r e t a f r o m r a t s r eceivi n g r epe a t ed o r a l doses ( G r o u p H).

Changes in biotransformation. Ap- p r op r i a t e q u a li t a t ive a n d q u a n t i t a t ive a ss a y m e t h odolog y s h a ll be u sed t o co m p a r e t h e co m posi t io n of r a dio- a c t ive co m po un ds s u bs t a n ces i n exc r e t a f r o m t h e r a t s r eceivi n g a s i n gle o r a l dose ( G r o u ps B a n d C) wi t h t h ose i n t h e exc ex- c r e t a f r o m r a t s r eceivi n g r epe a t ed o r a l doses ( G r o u p HF ).

Changes in biotransformation. Ap- p r op r i a t e q u a li t a t ive a n d q u a n t i t a t ive a ss a y m e t h odolog y ods s h a ll be u sed t o co m - p a r e t h e co m posi t io n of r a dio- dio a c t ive co m po un ds i n exc r e t a f r o m r a t s r eceivi eceiv- i n g a s i n gle o r i nh a l dose a t io n expos ur e ( G r o u ps B a n d C) wi t h t h ose i n a t h e exc r e t a f r o m r a t s r eceivi n g r epe a t ed o r i nh a l doses a t io n expo- s ur es ( G r o u p HF ).