Common use of Analytical methodology Clause in Contracts

Analytical methodology. Concentrations of LOXO-305 in plasma will be determined using a validated bioanalytical method. Specifics of the bioanalytical methods will be provided in a separate document. The concentrations of total and unbound LOXO-305 will be determined in a sample of predose plasma fortified with a known concentration of LOXO-305. The unbound fraction will be calculated based on total and unbound LOXO-305 levels. Samples of plasma may be analyzed for exploratory analyses of metabolites. If such analyses are conducted, the results will be reported separately by the Sponsor.

Analytical methodology. Concentrations of LOXO-305 in plasma will be determined using a validated bioanalytical method. Specifics of the bioanalytical methods will be provided in a separate document. The concentrations of total and unbound LOXO-305 will be determined in a sample of predose plasma fortified with a known concentration of LOXO-305. The unbound fraction fu will be calculated based on total and unbound LOXO-305 levels. Samples of plasma may be analyzed for exploratory analyses of metabolites. If such analyses are conducted, the results will be reported separately by the Sponsor.