Slope factor definition

Slope factor. , also known as "q1*", means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

Slope factor means the plausible upper-bound estimate of the probability of a response (cancer) per unit intake of chemical over a lifetime. Also referred to as Potency Factor.

Slope factor means an upper bound estimate that approximates a 95 percent confidence limit of the increased cancer risk from a lifetime exposure to a contaminant. This estimate is expressed in units of the proportion of a population that is affected per milligram per day exposure to the contaminant per kilogram of body weight of the exposed individual.

Examples of Slope factor in a sentence

• Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

• Slope factor and carcinogen group of arsenic are those listed in IRIS under arsenic (inorganic); RfDs of chromium, mercury, and nickel are those listed in IRIS under chromium (VI), mercuric chloride, and nickel (soluble salts), respectively.

• Slope factor setting; (j) Shade factor setting; and (k) Irrigation uniformity or efficiency setting.

• Therefore, in this study, it is necessary to study the anticancer and antioxidant test of Dysphania ambrosioides L.

• It Slope factor is expressed in milligrams per kilogram per day of exposure to the chemical in question.

• Where: C = Concentration of contaminant (soil: mg/kg, water: mg/l) RF = Risk factor For protection from cancer health risks:RF = TR ÷ SFWhere: TR = Target cancer risk (unitless)SF = Slope factor [(mg/kg)/day]-1 for a route of exposure; see paragraph “c” for source.

• Materials 35 that are damaged beyond repair as a result of the Contractor’s operations shall be disposed of as 36 provided elsewhere in the Contract Documents and replaced at the Contractor’s expense; or, at the 37 discretion of the District Representative, the estimated cost of replacement may be deducted from any 38 moneys due or to become due to the Contractor.

• Slope factor is the cancer risk (proportion affected) per unit of dose.

• Secondary Maximum Contaminant Level (SMCL) is given if applicable.B RfD: Chronic oral reference dose for non-carcinogenic toxic health effects based on findings of No Observable Adverse Effect Level (NOAEL) or Lowest Observable Adverse Effect Level (LOAEL).C SF: Slope factor is the upper-bound incremental risk of developing cancer due to lifetime exposure to a particular unit intake.D Chronic refers to the health effects due to long term exposure to the contaminant (e.g., exposure over many years).

• CovariateAACN – Altitude above channel network; LS – Length of Slope factor; SMU’s – Soil map units.

More Definitions of Slope factor

Slope factor means the incremental rate of cancer development calculated using a linearized multistage model or other appropriate model. It is expressed in milligrams per kilogram per day of exposure to the chemical in question and is also known as q1*.

Slope factor or "Q1*" means the incremental rate of cancer development calculated through use of a linearized multistage model or other appropriate model. It is expressed in (mg/kg/day) of exposure to the chemical in question.

Slope factor means the upperbound estimate of probability in the occurrence of excess cancer risk (increase in cancer risk over the background risk) associated with a specific carcinogen for an individual who is exposed to a unit of intake over lifetime. The unit for a slope factor is the probability per unit intake, i.e., the inverse of milligram per kilogram body weight (mg/Kg/day)-1.