Mutagenesis definition

Mutagenesis means the in vitro, in vivo, or in silico introduction of mutations into the DNA sequence encoding an antibody.
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Mutagenesis means the process of producing a change in the genetic material of cells.
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Mutagenesis means mutagenesis is the process by which an organism’s DNA change, resulting in a gene mutation. A mutation is a permanent and heritable change in genetic material, which can result in altered protein function and phenotypic changes;
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Examples of Mutagenesis in a sentence

  • For clarity, the Lead Success Factors for each Lead will include a requirement that the relevant Hit (or antibody that comprises the sequence of a Hit or is derived through Mutagenesis of a Hit) induces a functional response or response via an acceptable Target-specific mechanism.

  • Mutagenesis experiments on the adenosine A2B receptor show that the H7.42E receptor is no longer expressed suggesting a role for this residue in receptor stability and/or expression of this adenosine receptor subtype.

  • Mutagenesis: a word made up of “mutant” and “genesis”, signifying the creation of mutants.

  • Mutagenesis techniques are frequently and successfully applied to study their interaction with ligands, their mechanism of activation and their interaction with G proteins.

  • Nevertheless, we studied all three cysteines as possible sites of 14-3-3 oxidation and generated two 14-3-3 mutants using site-directed mutagenesis (QuikChange Site-directed Mutagenesis Kit, Stratagene).

  • Investigated domain; receptor Domain size (amino acids) Number mutants of Number of single point mutants of selected mutants of interest Mutagenesis method Ref.

  • Mutagenesis to generate Rep-K372A for cloning into pAV2 was performed on this plasmid.

  • Site-directed, Ligase-Independent Mutagenesis 710 (SLIM): a single-tube methodology approaching 100% efficiency in 4 h.

  • Chromosome fragility in dairy cows exposed to dioxins and dioxin-like PCBs. Mutagenesis 2011;26:269-72.

  • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 490(2), 159-169.