Lowest observed adverse effect level definition

Lowest observed adverse effect level or "LOAEL" means the lowest tested dose or concentration of a substance that resulted in an observed adverse effect in exposed test organisms when all higher doses or concentrations resulted in the same or more severe effects.
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Lowest observed adverse effect level or “LOAEL” means the lowest concentration of a hazardous substance at which there is a statistically or biologically significant increase in the frequency or severity of an adverse effect between an exposed population and a control group.
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Lowest observed adverse effect level or "LOAEL" means the low- est concentration of a hazardous substance at which there is a statis- tically or biologically significant increase in the frequency or se- verity of an adverse effect between an exposed population and a con- trol group.
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Examples of Lowest observed adverse effect level in a sentence

  • However, asset allocations to European property and credit have reduced performance.

  • A clinical test for detecting lead in living humans LOAEL Lowest observed adverse effect level.

  • Repeated dose toxicity - Lowest observed adverse effect level - 300 mg/kg Rat - male + female(ECHA) liver - Practical/human experience.

  • Summarised toxic risk values for fluoride (Source: TERA (toxicology excellence for risk assessment)) Organization NameAgency for Toxic Substances Disease registry (ATSDR) **NOAEL = No observed adverse effect level; *LOAEL = Lowest observed adverse effect level.

  • Margin of Exposure; NOAEL = No observed adverse effect level; and LOAEL = Lowest observed adverse effect level.

  • The Observed Effect Levels are as follows: ▲ Significant observed adverse effect level: This is the level of noise exposure above which significant adverse effects on health and quality of life occur; ▲ Lowest observed adverse effect level: This is the level of noise exposure above which adverse effects on health and quality of life can be detected; and ▲ No observed effect level: This is the level of noise exposure below which no effect at all on health or quality of life can be detected.

  • The National Planning and Policy Framework (NPPF) describes observed effect levels for noise as below: • Significant observed adverse effect level above which significant adverse effects on health and quality of life occur • Lowest observed adverse effect level: this is the level of noise exposure above which adverse effects on health and quality of life can be detected • No observed effect level: this is the level of noise exposure below which no effect at all on health or quality of life can be detected.

  • In this study the only relevant route of exposure is dermal exposure and thus Dtotal =Dder.The risk assessment is performed by calculating the Risk Characterisation Ratio (RCR) from the Derived No Effect Level (DNEL): RCR = Exposure (Dtotal )/DNELDNEL is calculated from NOAEL ( No observed adverse effect level) or LOAEL( Lowest observed adverse effect level) which are test data of a given effect for animals like rats or mice.

  • PPG paragraph 004 addresses the observed effect levels:• Significant observed adverse effect level: This is the level of noise exposure above which significant adverse effects on health and quality of life occur.• Lowest observed adverse effect level: this is the level of noise exposure above which adverse effects on health and quality of life can be detected.• No observed effect level: this is the level of noise exposure below which no effect at all on health or quality of life can be detected.

  • The ADI concept has often been used as a tool in reaching risk management decisions with an equation as follows: Acceptable Daily Intake (ADI) = NOAEL (or LOAEL)/(UF*MF) (Eq. 1) NOAEL = No observed adverse effect level LOAEL = Lowest observed adverse effect level UF = uncertainty factor MF = modifying factor In this equation the NOAELs (or LOAELs) that are derived directly from toxicological studies, may be modified by both an UF and MF.


More Definitions of Lowest observed adverse effect level

Lowest observed adverse effect level or "LOAEL" means the low- est concentration of a hazardous substance at which there is a statis-
Sample 1
Lowest observed adverse effect level or "LOAEL" means the lowest concentration of a hazardous substance at which there is a statis- tically or biologically significant increase in the
Sample 1Sample 2
Lowest observed adverse effect level or "LOAEL" means the lowest tested dose or concentration of a substance which results in an observed
Sample 1

Related to Lowest observed adverse effect level

  • SPAC Material Adverse Effect means any Effect that, individually or in the aggregate with all other Effects, is or would reasonably be expected to (a) have a material adverse effect on the business, condition (financial or otherwise), assets, liabilities or operations of the SPAC; or (b) prevent, materially delay or materially impede the performance by the SPAC or Merger Sub of their respective obligations under this Agreement or the consummation of the Merger or any of the other Transactions; provided, however, that none of the following shall be deemed to constitute, alone or in combination, or be taken into account in the determination of whether, there has been or will be a SPAC Material Adverse Effect: (i) any change or proposed change in or change in the interpretation of any Law (including any COVID-19 Measures) or GAAP; (ii) events or conditions generally affecting the industries or geographic areas in which the SPAC operates; (iii) any downturn in general economic conditions, including changes in the credit, debt, securities, financial or capital markets (including changes in interest or exchange rates, prices of any security or market index or commodity or any disruption of such markets); (iv) acts of war, sabotage, civil unrest, terrorism, epidemics, pandemics or disease outbreaks (including COVID-19) or any escalation or worsening of any such acts of war, sabotage, civil unrest, terrorism, epidemics, pandemics or disease outbreaks, or changes in global, national, regional, state or local political or social conditions; (v) any hurricane, tornado, flood, earthquake, natural disaster, or other acts of God; (vi) any actions taken or not taken by the SPAC as required by this Agreement or any Ancillary Agreement; (vii) any Effect attributable to the announcement or execution, pendency, negotiation or consummation of the Merger or any of the other Transactions (including any redemptions by any stockholders of the SPAC); or (viii) any actions or failures to take action, in each case, which the Company has requested or to which it has consented or which actions are contemplated by this Agreement, except in the cases of the foregoing clauses (i) through (iii), to the extent that the SPAC is materially and disproportionately affected thereby as compared with other participants in the industries in which the SPAC operates.

  • Company Material Adverse Effect means any material adverse effect with respect to the Company, taken as a whole, or any change or effect that adversely, or is reasonably expected to adversely, affect the ability of the Company to maintain its current business operations or to consummate the transactions contemplated by this Agreement in any material respect.

  • Material Adverse Effect shall have the meaning assigned to such term in Section 3.1(b).

  • Material Adverse Change means any material adverse change in the business, condition (financial or otherwise), operations, performance, properties or prospects of the Borrower or the Borrower and its Subsidiaries taken as a whole.

  • Highest-level owner means the entity that owns or controls an immediate owner of the offeror, or that owns or controls one or more entities that control an immediate owner of the offeror. No entity owns or exercises control of the highest level owner.