Antisense means the production and/or use for therapeutic purposes of stabilized synthetic oligonucleotides.
Antisense means [*];
Antisense means inhibiting or preventing in vivo expression in a human or animal of a gene product by use of an oligonucleotide or modified oligonucleotide which binds to RNA or DNA to prevent and/or impair expression of the gene product. 1.4 "Blocking Claim" shall mean a claim under any patent application or granted patent anywhere in the world which generically but not specifically covers (i) any and all compounds (and/or the use thereof) which interact with or prevent interaction with a specified Target and/or (ii) any and all antibodies (and/or the use thereof) against a specific Target or Therapeutic Protein. The following are examples of "blocking claims": (1) a compound which interacts with receptor X; (2) a compound which prevents binding between receptor X and its ligand, (3) a process for activating receptor X, comprising: contacting receptor X with a compound which binds thereto and activates the receptor; (4) a process for preventing activation of receptor X comprising: contacting receptor X with a compound which prevents binding between receptor X and its ligand. 1.5 "Bioinformatics" shall mean computer software and know-how useful for the analysis, comparison, and curation of human nucleic acid and protein sequences, and information related to such sequences; and software for the construction and maintenance of databases for the compilation of such sequences and their associated information; each as developed through the end of the Initial Research Term. Bioinformatics shall include software for the prediction of the three-dimensional structure of proteins from primary sequence information but Bioinformatics shall not include software for rational drug design based on such three-dimensional structure. 1.6 "Collaboration Agreement"shall mean the Collaboration Agreement entered into between SB and HGS effective as of May 19, 1993, as amended and/or superseded from time to time. 1.7 "Collaboration Partner Agreement" shall mean an agreement between or among SB and/or HGS and (1) Synthelabo substantially in accordance with a memorandum of intent dated March 11, 1996; (2) SP substantially in accordance with a memorandum of intent dated April 21, 1996; (3) Takeda substantially in accordance with the SB/Takeda Collaboration and License Agreement dated June 5, 1995; and (4) a COLLABORATION PARTNER, in addition to (1) and (2) or substituted for (1) or (2), wherein
Examples of Antisense in a sentence
Antisense correction of SMN2 splicing in the CNS rescues necrosis in a type III SMA mouse model.
Antisense Inhibition of Apolipoprotein C-III in Patients with Hypertriglyceridemia.
Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.
Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis.
Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy.
More Definitions of Antisense
Antisense has the meaning ascribed to such term in Section 2.36(i).
Antisense means a nucleic acid, or a functional analog, derivative or homologue thereof, that (a) is complementary to a segment of DNA of a target Gene or such target Gene's cognate RNA, and (b) upon delivery by any means, alters the transcription, processing, elaboration, RNA expression, or protein production of or by such target Gene.
Antisense means the use of an ASO to modulate expression of a target gene.
Antisense means inhibiting or preventing in vivo expression in a human or animal of a gene product by use of an oligonucleotide or modified oligonucleotide which binds to RNA or DNA to prevent and/or impair expression of the gene product. 1.5. "BLOCKING CLAIM" shall mean a claim under any patent application or granted patent anywhere in the world which generically but not specifically claims (i) any and all compounds (and/or the use thereof) which interact with or prevent interaction with a specified TARGET which is a COLLABORATION PRODUCT and/or (ii) any and all antibodies (and/or the use thereof) against a specific TARGET or THERAPEUTIC PROTEIN each of which is a COLLABORATION PRODUCT. The following are examples of "blocking claims": (1) a compound which interacts with, or is capable of interacting with, receptor X; (2) a compound which prevents binding between or to receptor X and its ligand, (3) a process for activating receptor X, comprising: contacting receptor X with a compound which binds thereto and activates the receptor; (4) a process for preventing activation of receptor X comprising contacting receptor X with a compound which prevents binding between receptor X and its ligand.
Antisense means inhibiting or preventing in vivo expression in a human or animal of a gene product by use of an oligonucleotide or modified oligonucleotide which binds to RNA or DNA to prevent and/or impair expression of the gene product. 1.5 "BLOCKING CLAIM" shall mean a claim under any patent application or granted patent anywhere in the world which generically but not specifically claims (i) any and all compounds (and/or the use thereof) which interact with or prevent interaction with a specified TARGET which is a PRODUCT (i.e., an omnibus claim) and/or (ii) any and all antibodies (and/or the use thereof) against a specified THERAPEUTIC PROTEIN (i.e., an omnibus claim). The following are representative but not exclusive examples of claim language for "BLOCKING CLAIMS": (1) a compound which interacts with receptor X; (2) a compound which prevents binding between receptor X and its ligand, (3) a process for activating receptor X, comprising: contacting receptor X with a compound which binds thereto and activates the receptor; (4) a process for preventing activation of receptor X comprising contacting receptor X with a compound which prevents binding between receptor X and its ligand , and (5) a compound which is capable of interacting with a receptor X. 1.6 "cDNA" shall mean complementary DNA prepared from human messenger RNA. 1.7 "COLLABORATION AGREEMENT" shall mean the Collaboration Agreement entered into between SB and HGS effective as of May 19, 1993, as amended or superseded from time to time, a copy of the version to be in effect on the EFFECTIVE DATE having been provided to SP prior to the EFFECTIVE DATE.
Antisense means inhibiting or preventing in vivo expression of a gene product in a human or animal through the use of an oligonucleotide or modified oligonucleotide which binds to RNA or DNA.
Antisense means inhibiting or preventing in vivo expression in a human or animal of a gene product by use of an oligonucleotide or modified oligonucleotide which binds to RNA or DNA and prevents and/or impairs expression of the gene product. 1.3 "DIAGNOSTICS" shall mean any product, process, substance, composition or service intended to predict, detect or identify a disease or determine the presence of a pathologic condition in a human. 1.4 "DISCOVERED" shall mean with respect to any product, process, substance, composition or service, the earlier of the following events (i) the specific disclosure of such product, process, substance, composition or service in a patent application filed by the discovering party or (ii) the specific disclosure of such product, process, substance, composition 2