Abbott Architect Method Principle definition

Abbott Architect Method Principle. The assay is an automated, two step immunoassay to detect qualitatively IgG antibodies to SARS-Cov-2 in plasma and serum samples using a chemiluminescent microparticle immunoassay (CMIS). The resulting chemiluminescent reaction is measured as a relative light unit (RLU). There is a direct relationship between the amount of the IgG antibodies to SARS-Cov-2 in the sample and the RLU detected by the system optics. The relationship is reflected in the calculated index (S/C). The presence or absence of the IgG antibodies to SARS-Cov-2 in the sample is determined by comparing the chemiluminescent RLU in the reaction to the calibrator RLU. Abbott Architect processes using a cut off index of 1.4, results <1.4 are interpreted as negative, results >1.4 are interpreted as positive. Boditech iCHROMA Method Principle: The test uses a sandwich immunodetection method; fluorescence labelled conjugates in a dried detection buffer binds to antibody in sample, forming antibody-antigen complexes, and migrates onto nitrocellulose matrix to be captured by the other immobilized anti-human IgG on test strip. The more antigen-antibody complexes lead to stronger fluorescence signal by the detector antigen which is processed by iCHROMA™.The iCHROMA™ processes the signal using a cut off index of 0.9 – 1.1, results <0.9 are interpreted as negative, results between 0.9 and 1.1 are interpreted as indeterminate and results >1.1 are interpreted as positive. Fifty plasma samples were collected from staff and patients of a GP practice with and without symptoms of Covid-19. The patients that were highly suspected on having Covid-19 had their swab samples taken and the samples were sent off to a private laboratory to have SARS-Cov-2 PCR assay done. The samples were run on the Abbott Architect 1 System using the SARS-CoV-2 IgG assay, 20 (40%) of the plasma samples assayed were identified as positive and the remaining 30 (60%) of the plasma samples assayed were identified as negative. The plasma samples were subsequently run on the iCHROMA using the Covid-19 antibody test. All the 20 positive samples (100%) were identified by the Boditech iCHROMA method as positive and 27 (90%) of the 30 negative samples were identified as negative by the Boditech iCHROMA method. The 3 negative samples identified by the Abbott SARS-CoV-2 IgG assay, as positive by the Boditech iCHROMA method might be due to the increased sensitivity of the Boditech iCHROMA method or reduced sensitivity of the Abbott SARS-CoV-2 I...
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Related to Abbott Architect Method Principle

  • Design Criteria Professional means a firm who holds a current certificate of registration under Chapter 481 of the Florida Statutes, to practice architecture or landscape architecture, or a firm who holds a current certificate as a registered engineer under Chapter 471 of the Florida Statutes, to practice engineering, and who is employed by or under contract to the District to provide professional architect services, landscape architect services, or engineering services in connection with the preparation of the Design Criteria Package.

  • Project Architect means the architect retained by Lessee to design and supervise construction of the Improvements.

  • Non-Participating Certified Clinical Nurse Specialist means a Certified Clinical Nurse Specialist who does not have a written agreement with the Claim Administrator or another Blue Cross and/or Blue Shield Plan to provide services to you at the time services are rendered.

  • Construction Change Directive means a written order prepared by Owner Parties and signed by Owner directing Contractor to perform a change in the Work prior to agreeing to a change, if any, to the Contract Time, schedule of performance of the Work, Contract Sum, or Contractor’s compensation.

  • Application Review Start Date means the later date of either the date on which the District issues its written notice that the Applicant has submitted a completed Application or the date on which the Comptroller issues its written notice that the Applicant has submitted a completed Application and as further identified in Section 2.3.A of this Agreement.