Collaboration and License Agreement by And Sample Contracts

AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT BY AND BETWEEN ASTELLAS US LLC (FORMERLY FUJISAWA HEALTHCARE, INC.) AND
Collaboration and License Agreement by And • September 6th, 2005 • Cv Therapeutics Inc • Biological products, (no disgnostic substances)

This Amendment (“Amendment”) is entered into, effective as of August 30, 2005 (the “Amendment Effective Date”), by and between Astellas US LLC (“Astellas”, successor-in-interest to Fujisawa Healthcare, Inc., the original signatory to the Agreement defined below), and CV Therapeutics, Inc. (“CVT”) (Astellas and CVT being individually referred to herein as a “Party” and collectively as the “Parties”), with reference to the following facts and circumstances:

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