0001564590-16-013732 Sample Contracts

THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • February 29th, 2016 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS THIRD AMENDMENT (this “Amendment”) to the Loan and Security Agreement, dated as of August 11, 2015, as previously amended pursuant to that certain First Amendment thereto dated as of September 28, 2015 and that certain Second Amendment thereto dated as of December 31, 2015 (as so amended, the “Loan Agreement”), is made by and among MAST THERAPEUTICS, INC., a Delaware corporation (“Borrower”), HERCULES CAPITAL, INC. (formerly known as HERCULES TECHNOLOGY GROWTH CAPITAL, INC.), a Maryland corporation, as administrative agent (“Agent”), and the lender party hereto (“Lender”), and shall be effective as of February 25, 2016.

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SECOND AMENDMENT TO WARRANT AGREEMENT
Warrant Agreement • February 29th, 2016 • Mast Therapeutics, Inc. • Pharmaceutical preparations • California

THIS SECOND AMENDMENT (this “Amendment”), dated as of February 25, 2016, to the Warrant Agreement to Purchase Shares of the Common Stock of Mast Therapeutics, Inc., dated as of August 11, 2015, as previously amended pursuant to that certain First Amendment thereto dated as of September 28, 2015, (as so amended, the “Warrant Agreement”), is made by and between MAST THERAPEUTICS, INC., a Delaware corporation (the “Company”), and HERCULES TECHNOLOGY III, L.P., a Delaware limited partnership (the “Warrantholder”).

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