0001493152-26-042672 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • September 15th, 2026 • GT Biopharma, Inc. • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of September 14, 2026, between GT Biopharma, Inc., a Delaware corporation (the “Company”), and each of the several purchasers signatory hereto (each such purchaser, a “Purchaser” and, collectively, the “Purchasers”).

COMMON STOCK VESTING WARRANTS GT Biopharma, Inc.
Common Stock Vesting Agreement • September 15th, 2026 • GT Biopharma, Inc. • Pharmaceutical preparations

THIS COMMON STOCK VESTING WARRANT (this “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after September 14, 2026 (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on the five-year anniversary of the date that the applicable Warrant Shares vest hereunder (each, a “Termination Date”) but not thereafter, to subscribe for and purchase from GT Biopharma, Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock; provided, however, the exercisability of this Warrant shall vest ratably from time to time in proportion to the Holder’s (or its permitted assigns) exercise of such Holder’s Greenshoe Rights pursuant to Section 2.4 of the Purchase Agreement compared with all Greenshoe Securities issuable to the Holder

LOCK-UP AGREEMENT
Lock-Up Agreement • September 15th, 2026 • GT Biopharma, Inc. • Pharmaceutical preparations

Re: Securities Purchase Agreement, dated as of September 14, 2026 (the “Purchase Agreement”), between GT Biopharma, Inc. (the “Company”) and the purchasers signatory thereto (each, a “Purchaser” and, collectively, the “Purchasers”)

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • September 15th, 2026 • GT Biopharma, Inc. • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of September 14, 2026, between GT Biopharma, Inc., a Delaware corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”).

COMMON STOCK PURCHASE WARRANT GT Biopharma, Inc.
Common Stock Purchase Warrant • September 15th, 2026 • GT Biopharma, Inc. • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (this “Warrant”) certifies that, for value received, _____________ or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after September 14, 2026 (the “Initial Exercise Date”) and on or prior to 5:00 p.m. (New York City time) on September 14, 2031 (the “Termination Date”) but not thereafter, to subscribe for and purchase from GT Biopharma, Inc., a Delaware corporation (the “Company”), up to ______ shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).