0001299933-16-002299 Sample Contracts

FOURTH AMENDMENT TO LEASE
Lease • April 15th, 2016 • Heron Therapeutics, Inc. /De/ • Pharmaceutical preparations

This Fourth Amendment to Lease (“Amendment”) is made and entered into effective as of April 11, 2016 (the “Effective Date”), by and between METROPOLITAN LIFE INSURANCE COMPANY, a New York corporation (“Landlord”), and HERON THERAPEUTICS, INC., a Delaware corporation, f/k/a AP Pharma, Inc., a Delaware corporation, f/k/a Advanced Polymer Systems, a Delaware corporation (“Tenant”), with reference to the following facts (“Recitals”):

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