0001193125-26-391682 Sample Contracts

EXCHANGE AGREEMENT
Exchange Agreement • September 15th, 2026 • Jaguar Health, Inc. • Pharmaceutical preparations • Utah

This Exchange Agreement (this “Agreement”) is entered into as of July 7, 2026 (the “Effective Date”) by and between Streeterville Capital, LLC, a Utah limited liablity company (“Lender”), and Jaguar Health, Inc., a Delaware corporation (“Borrower”). Capitalized terms used in this Agreement without definition shall have the meanings given to them in the Royalty Interest (as defined below).

PRE-FUNDED COMMON STOCK PURCHASE WARRANT JAGUAR HEALTH, INC.
Pre-Funded Common Stock Purchase Warrant • September 15th, 2026 • Jaguar Health, Inc. • Pharmaceutical preparations • New York

THIS PRE-FUNDED COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, Joshua Mailman or his or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the date hereof (the “Initial Exercise Date”) until this Warrant is exercised in full (the “Termination Date”) but not thereafter, to subscribe for and purchase from Jaguar Health, Inc., a Delaware corporation (the “Company”), up to 2,077,255 shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • September 15th, 2026 • Jaguar Health, Inc. • Pharmaceutical preparations • New York

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”), is dated as of September 12, 2026 (the “Execution Date”), by and among Jaguar Health, Inc., a Delaware corporation (the “Company”), and Joshua Mailman, a resident of the State of New York (the “Purchaser”).

EXCHANGE AGREEMENT
Exchange Agreement • September 15th, 2026 • Jaguar Health, Inc. • Pharmaceutical preparations • New York

This Exchange Agreement (this “Agreement”) is entered into as of September 11, 2026 (the “Effective Date”) by and between Lincoln Alternative Strategies LLC, a Delaware limited liability company (“Lender”), and Jaguar Health, Inc., a Delaware corporation (“Borrower”). Capitalized terms used in this Agreement without definition shall have the meanings given to them in the Replacement Note (as defined below).