0001193125-18-159200 Sample Contracts

KARYOPHARM THERAPEUTICS INC. NONSTATUTORY STOCK OPTION AGREEMENT Inducement Grant
Nonstatutory Stock Option Agreement • May 10th, 2018 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Delaware

This option satisfies in full all commitments that the Company has to the Participant with respect to the issuance of stock, stock options or other equity securities.

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THIRD AMENDMENT TO LEASE
Lease • May 10th, 2018 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

This THIRD AMENDMENT TO LEASE (this “Amendment”) is dated as of February 28, 2018 (the “Effective Date”) and is hereby entered into by and between AG-JCM Wells Avenue Property Owner, LLC (“Landlord”), a Delaware limited liability company, with an address of c/o Jumbo Capital Management, LLC, 1900 Crown Colony Drive, 4th Floor, Quincy, Massachusetts 02169, and Karyopharm Therapeutics Inc. (“Tenant”), a Delaware corporation, with an address of 85 Wells Avenue, 2nd Floor, Newton, Massachusetts 02459.

Confidential Materials omitted and filed separately with the Securities and Exchange Commission. Double asterisks denote omissions. ASSET PURCHASE AGREEMENT by and between BIOGEN MA INC. and KARYOPHARM THERAPEUTICS INC. DATED AS OF JANUARY 24, 2018
Asset Purchase Agreement • May 10th, 2018 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Massachusetts

This Asset Purchase Agreement, dated as of January 24, 2018, is made by and between Karyopharm Therapeutics Inc., a Delaware corporation (with its principal corporate offices at 85 Wells Avenue, Newton, MA 02459) (“Seller”) and Biogen MA Inc., a Massachusetts corporation (with its principal corporate offices at 225 Binney Street, Cambridge, MA 02142) (“Purchaser”). Seller and Purchaser are collectively referred to herein as the “Parties” and individually as a “Party.”

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