0001193125-18-022383 Sample Contracts

REGULUS THERAPEUTICS INC., Issuer AND [TRUSTEE], Trustee INDENTURE Dated as of [●], 20__ Debt Securities
Indenture • January 29th, 2018 • Regulus Therapeutics Inc. • Pharmaceutical preparations • New York

INDENTURE, dated as of [•], 20 , among Regulus Therapeutics Inc., a Delaware corporation (the “Company”), and[TRUSTEE], as trustee (the “Trustee”):

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REGULUS THERAPEUTICS INC. and , As Warrant Agent FORM OF COMMON STOCK WARRANT AGREEMENT Dated As Of REGULUS THERAPEUTICS INC. Form of Common Stock Warrant Agreement
Common Stock Warrant Agreement • January 29th, 2018 • Regulus Therapeutics Inc. • Pharmaceutical preparations • New York

COMMON STOCK WARRANT AGREEMENT (this “Agreement”), dated as of between REGULUS THERAPEUTICS INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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REGULUS THERAPEUTICS INC. and , As Warrant Agent FORM OF DEBT SECURITIES WARRANT AGREEMENT Dated As Of REGULUS THERAPEUTICS INC. Form of Debt Securities Warrant Agreement
Warrant Agreement • January 29th, 2018 • Regulus Therapeutics Inc. • Pharmaceutical preparations • New York

DEBT SECURITIES WARRANT AGREEMENT (this “Agreement”), dated as of between REGULUS THERAPEUTICS INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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REGULUS THERAPEUTICS INC. and , As Warrant Agent FORM OF PREFERRED STOCK WARRANT AGREEMENT Dated As Of REGULUS THERAPEUTICS INC. Form of Preferred Stock Warrant Agreement
Preferred Stock Warrant Agreement • January 29th, 2018 • Regulus Therapeutics Inc. • Pharmaceutical preparations • New York

PREFERRED STOCK WARRANT AGREEMENT (the “Agreement”), dated as of between REGULUS THERAPEUTICS INC., a Delaware corporation (the “Company”), and , a [corporation] [national banking association] organized and existing under the laws of and having a corporate trust office in , as warrant agent (the “Warrant Agent”).

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