0001193125-15-370974 Sample Contracts

KARYOPHARM THERAPEUTICS INC.
Karyopharm Therapeutics Inc. • November 9th, 2015 • Pharmaceutical preparations • Massachusetts

Subject to your execution below, this letter hereby amends the offer letter, dated March 3, 2014, between you and Karyopharm Therapeutics Inc. (the “Company”), which was previously amended and restated on January 23, 2015, and provides for the following terms of employment:

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KARYOPHARM THERAPEUTICS INC. RESTRICTED STOCK UNIT AGREEMENT
Restricted Stock Unit Agreement • November 9th, 2015 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations • Delaware

This Restricted Stock Unit Agreement (this “Agreement”) is made as of the agreement date set forth below (the “Agreement Date”) between Karyopharm Therapeutics Inc. (the “Company”), a Delaware corporation, and the participant set forth below (the “Participant”) pursuant to the Company’s 2013 Stock Incentive Plan. The terms and conditions attached hereto are also a part hereof.

FIRST AMENDMENT TO CONSULTING AGREEMENT BETWEEN KARYOPHARM THERAPEUTICS AND MIRZA CONSULTING
Consulting Agreement • November 9th, 2015 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

WHEREAS, Karyopharm Therapeutics Inc. (“Karyopharm”) and Mirza Consulting (“Consultant”) previously entered into a Consulting Agreement effective as of September 1, 2012 (the “Agreement”);

SECOND AMENDMENT TO LEASE
Lease • November 9th, 2015 • Karyopharm Therapeutics Inc. • Pharmaceutical preparations

This Second Amendment to Lease (this “Second Amendment”) is entered into as of October 22, 2015, by and between NS WELLS ACQUISITION LLC, a Delaware limited liability company (the “Landlord”), and KARYOPHARM THERAPEUTICS INC., a Delaware corporation (the “Tenant”).

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