0001193125-15-116070 Sample Contracts

Contract
Warrant Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Massachusetts

THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNSEL) REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS.

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GELESIS, INC. SIXTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Delaware

THIS AGREEMENT is made as of March 6, 2015 (the “Effective Date”) between Gelesis, Inc., a Delaware corporation (the “Company”), and the other stockholders listed on the Schedule of Stockholders attached hereto, as the same may be amended from time to time (each, individually, a “Stockholder” and collectively, the “Stockholders”).

Contract
Warrant Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Massachusetts

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL (WHICH MAY BE COMPANY COUNSEL) REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY APPLICABLE STATE SECURITIES LAWS.

GELESIS INC. Nonstatutory Stock Option Agreement Granted Under 2006 Stock Incentive Plan
Stock Option Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations
GELESIS, INC. Incentive Stock Option Agreement Granted Under 2006 Stock Incentive Plan
Gelesis Inc • April 1st, 2015 • Pharmaceutical preparations
THIS AMENDED AND RESTATED WARRANT AND THE SHARES OF PREFERRED STOCK ISSUED UPON ITS EXERCISE ARE SUBJECT TO THE RESTRICTIONS ON TRANSFER SET FORTH IN SECTION 5 OF THIS WARRANT
Gelesis Inc • April 1st, 2015 • Pharmaceutical preparations • Delaware

Gelesis, Inc., a Delaware corporation (the “Company”), for value received, hereby certifies that , or its registered assigns (the “Registered Holder”), is entitled, subject to the terms and conditions set forth below, to purchase from the Company, at any time or from time to time on or after Original Issue Date and before 5:00 p.m. (Boston time) on the Expiration Date (as defined below), Warrant Shares (as defined below), at a purchase price of $0.01 per share. The purchase price per share, as adjusted from time to time pursuant to the provisions of this Warrant, is hereinafter referred to as the “Purchase Price.” This Warrant has been issued pursuant to that certain Series A-4 Stock and LLC Common Share Purchase Agreement, dated August 16, 2013, by and among the Company and the signatories thereto (the “Purchase Agreement”) and all such Warrants that are so issued are collectively referred to herein as the “Series A-4 Warrants”.

CONTRACT FOR THE USE OF SPACES AND FURNITURE BETWEEN
Spaces and Furniture • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations

UNIVERSITY OF SALENTO (hereinafter called University of Salento) with seat in Lecce, P.zza Tancredi nr. 7, Fiscal Code 80008870752, in the person of the Dean Prof. Eng. Domenico Laforgia born in Bari on 22nd June and domiciled for this office at the above-mentioned seat, authorized to the signature of this contract with D.R. nr. 968 dated 29th August 2011

ROYALTY AND SUBLICENSE INCOME AGREEMENT
Royalty and Sublicense Income Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Delaware

This ROYALTY ASSIGNMENT AGREEMENT (the “Agreement”), dated as of December 18, 2009, is by and among (i) PureTech Ventures, LLC, a Delaware limited liability company, (“PureTech”), (ii) Gelesis, Inc., a Delaware corporation, (“Gelesis-US”) and (iii) Gelesis LP (formerly AML-Dienstein B. V.), a Bermudan limited partnership (“Gelesis-Bermuda” and collectively with Gelesis-US, “Gelesis”).

AMENDED AND RESTATED MANAGEMENT SERVICES AND OVERHEAD AGREEMENT
Management Services • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Massachusetts

This Amended and Restated Management Services and Overhead Agreement (“Agreement”) is entered into to be effective as of May 25, 2011 by and between Gelesis, Inc., a Delaware Corporation (“Gelesis”) and PureTech Ventures, LLC (“PureTech”).

THIS AMENDED AND RESTATED WARRANT AND THE SHARES OF PREFERRED STOCK ISSUED UPON ITS EXERCISE ARE SUBJECT TO THE RESTRICTIONS ON TRANSFER SET FORTH IN SECTION 5 OF THIS WARRANT
Gelesis Inc • April 1st, 2015 • Pharmaceutical preparations • Delaware

Gelesis, Inc., a Delaware corporation (the “Company”), for value received, hereby certifies that One SRL, or its registered assigns (the “Registered Holder”), is entitled, subject to the terms and conditions set forth below, to purchase from the Company, at any time or from time to time on or after Original Issue Date and before 5:00 p.m. (Boston time) on the Expiration Date (as defined below), Warrant Shares (as defined below), at a purchase price of $0.01 per share. The purchase price per share, as adjusted from time to time pursuant to the provisions of this Warrant, is hereinafter referred to as the “Purchase Price.”

AMENDED AND RESTATED MASTER AGREEMENT
Master Agreement • April 1st, 2015 • Gelesis Inc • Pharmaceutical preparations • Massachusetts

This Amended and Restated Master Agreement (this “Agreement”), dated as of the 29th day of December, 2014 (the “Effective Date”), is by and among Gelesis, LLC, a Delaware, USA limited liability company with its principle place of business at 500 Boylston Street, Suite 1600, Boston, Massachusetts 02116, U.S.A.,

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