0001193125-15-056561 Sample Contracts

SUMMIT THERAPEUTICS PLC AND THE BANK OF NEW YORK MELLON As Depositary AND OWNERS AND HOLDERS OF AMERICAN DEPOSITARY SHARES Deposit Agreement
Deposit Agreement • February 20th, 2015 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

DEPOSIT AGREEMENT dated as of [Agreementdate] among SUMMIT THERAPEUTICS PLC, a company incorporated under the laws of England and Wales (herein called the Company), THE BANK OF NEW YORK MELLON, a New York banking corporation (herein called the Depositary), and all Owners and Holders (each as hereinafter defined) from time to time of American Depositary Shares issued hereunder.

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] American Depositary Shares Representing [ ] Ordinary Shares (Par Value £0.01 Per Share) SUMMIT THERAPEUTICS PLC UNDERWRITING AGREEMENT
Underwriting Agreement • February 20th, 2015 • Summit Therapeutics PLC • Pharmaceutical preparations • New York

The ADSs will be evidenced by American Depositary Receipts (“ADRs”) issued pursuant to that certain Deposit Agreement dated [ ], 2015 (the “Deposit Agreement”), by and among the Company, The Bank of New York Mellon, as depositary (the “Depositary”), and all holders and beneficial owners of ADSs issued thereunder. The Ordinary Shares to be issued in connection with, and represented by, the ADSs are hereinafter referred to as the “Underlying Securities.”

DEED OF INDEMNITY
Summit Therapeutics PLC • February 20th, 2015 • Pharmaceutical preparations • England
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