0001193125-09-071324 Sample Contracts

ANESIVA, INC., Issuer AND THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., Trustee INDENTURE Dated as of April 2, 2009 Senior Debt Securities
Indenture • April 2nd, 2009 • Anesiva, Inc. • Pharmaceutical preparations • New York

INDENTURE, dated as of April 2, 2009, among ANESIVA, INC., a Delaware corporation (the “Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as trustee (the “Trustee”):

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SUBLEASE
Sublease Agreement • April 2nd, 2009 • Anesiva, Inc. • Pharmaceutical preparations • California

THIS SUBLEASE AGREEMENT (“Sublease”) is made and entered into on March 27, 2009 by and between TITAN PHARMACEUTICAL, INC., a Delaware corporation (hereinafter “Sublessor”), and ANESIVA, INC., a Delaware corporation (hereinafter “Sublessee”).

AMENDMENT NO. 1 TO TO SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • April 2nd, 2009 • Anesiva, Inc. • Pharmaceutical preparations • California

This Amendment No. 1 to Securities Purchase Agreement is entered into as of April 1, 2009 (the “Amendment”) by and between certain of the investors set forth on Schedule 1 (the “Investors”) of the Securities Purchase Agreement, dated January 20, 2009 (the “Agreement”), which Investors constitute the Majority Investors, and Anesiva, Inc. (the “Company”). All capitalized terms not defined herein shall have the respective meanings set forth in the Agreement.

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