0001193125-08-204596 Sample Contracts

RELEASE
Cell Therapeutics Inc • October 1st, 2008 • Pharmaceutical preparations
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AMENDMENT OF SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 1st, 2008 • Cell Therapeutics Inc • Pharmaceutical preparations

This Amendment of Securities Purchase Agreement (this “Amendment”) is dated as of September 23, 2008. It amends the Securities Purchase Agreement (the “Agreement”) dated as of September 15, 2008, between Cell Therapeutics, Inc. and Enable Growth Partners LP.

SECOND AMENDMENT OF SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • October 1st, 2008 • Cell Therapeutics Inc • Pharmaceutical preparations

The Securities Purchase Agreement dated September 15, 2008 between Cell Therapeutics, Inc. (the “Company”) and Enable Growth Partners LP (“Enable”), and to which Enable Opportunity Partners LP and Pierce Diversified Master Strategy Fund LLC, Ena were also parties as to certain sections, as previously amended by an Amendment to Securities Purchase Agreement dated September 23, 2008 (as so amended, the “Securities Purchase Agreement”), is hereby further amended as follows, on and as of September 26, 2008.

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