0001193125-07-005696 Sample Contracts

FIRST AMENDMENT TO NOTE PURCHASE AGREEMENT AND SENIOR NOTE
Note Purchase Agreement and Senior Note • January 12th, 2007 • Monogram Biosciences, Inc. • In vitro & in vivo diagnostic substances

This FIRST AMENDMENT TO NOTE PURCHASE AGREEMENT AND SENIOR NOTE (this “Amendment”) is made as of January , 2007 by the undersigned parties to the Note Purchase Agreement, dated as of May 5, 2006 (as has been amended and as may be amended, restated or otherwise modified from time to time, the “Note Purchase Agreement”), among Monogram Biosciences, Inc. (the “Company”) and Pfizer Inc (the “Holder”). Capitalized terms used and not otherwise defined herein shall have the meanings assigned to such terms in the Note Purchase Agreement.

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MONOGRAM BIOSCIENCES, INC. as the Company and HIGHBRIDGE INTERNATIONAL LLC, as the Buyer REGISTRATION RIGHTS AGREEMENT Dated as of January 11, 2007
Registration Rights Agreement • January 12th, 2007 • Monogram Biosciences, Inc. • In vitro & in vivo diagnostic substances • New York

THIS REGISTRATION RIGHTS AGREEMENT (this “Agreement”), is entered into as of January 11, 2007, by and between Monogram Biosciences, Inc., a Delaware corporation (the “Company”), and Highbridge International LLC (the “Buyer”).

SUBORDINATION AGREEMENT
Subordination Agreement • January 12th, 2007 • Monogram Biosciences, Inc. • In vitro & in vivo diagnostic substances • New York

THIS SUBORDINATION AGREEMENT (“Agreement”) dated as of January , 2007, is entered into by and among U.S. Bank National Association, a national banking association organized and existing under the laws of the United States, as trustee (the “Trustee” and in its capacity hereunder as trustee, “Subordinated Creditor”), MONOGRAM BIOSCIENCES, INC., a Delaware corporation (the “Company”), and PFIZER INC., a Delaware corporation (the “Senior Creditor”).

MONOGRAM BIOSCIENCES, INC. and HIGHBRIDGE INTERNATIONAL LLC SECURITIES PURCHASE AGREEMENT Dated as of January 11, 2007 0% Convertible Senior Unsecured Notes due 2026
Securities Purchase Agreement • January 12th, 2007 • Monogram Biosciences, Inc. • In vitro & in vivo diagnostic substances • New York

THIS SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of January 11, 2007, by and between Monogram Biosciences, Inc., a Delaware corporation (the “Company”), and Highbridge International LLC (the “Buyer”).

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