0001193125-06-032360 Sample Contracts

COMMON STOCK PURCHASE WARRANT To Purchase Shares of Common Stock of PRO- PHARMACEUTICALS, INC.
Pro Pharmaceuticals Inc • February 15th, 2006 • Pharmaceutical preparations

THIS COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, (the “Holder”), is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after the 181st day following the date hereof (the “Initial Exercise Date”) and on or prior to the close of business on the five year anniversary of the Initial Exercise Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Pro-Pharmaceuticals, Inc., a Nevada corporation (the “Company”), up to shares (the “Warrant Shares”) of Common Stock, par value $.001 per share, of the Company (the “Common Stock”). The purchase price of one share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 2(b).

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SECURITIES PURCHASE AGREEMENT
Securities Purchase Agreement • February 15th, 2006 • Pro Pharmaceuticals Inc • Pharmaceutical preparations • New York

This Securities Purchase Agreement (this “Agreement”) is dated as of February , 2006 among Pro-Pharmaceuticals, Inc., a Nevada corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively the “Purchasers”).

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • February 15th, 2006 • Pro Pharmaceuticals Inc • Pharmaceutical preparations

This Registration Rights Agreement (this “Agreement”) is made and entered into as of February 14, 2006, among Pro-Pharmaceuticals, Inc., a Nevada corporation (the “Company”), and the several purchasers signatory hereto (each such purchaser is a “Purchaser” and collectively, the “Purchasers”).

7% CONVERTIBLE DEBENTURE DUE FEBRUARY , 2008
Pro Pharmaceuticals Inc • February 15th, 2006 • Pharmaceutical preparations • New York

THIS CONVERTIBLE DEBENTURE is one of a series of duly authorized and validly issued 7% Convertible Debentures of Pro-Pharmaceuticals, Inc., a Nevada corporation, having its principal place of business at 189 Wells Avenue, Newton, Massachusetts 02459 (the “Company”), designated as its 7% Convertible Debenture, due February , 2008 (this debenture, the “Debenture” and collectively with the other such series of debentures, the “Debentures”).

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