0001193125-05-180749 Sample Contracts

AMENDMENT TO COLLABORATION AND LICENSE AGREEMENT BY AND BETWEEN ASTELLAS US LLC (FORMERLY FUJISAWA HEALTHCARE, INC.) AND
Collaboration and License Agreement by And • September 6th, 2005 • Cv Therapeutics Inc • Biological products, (no disgnostic substances)

This Amendment (“Amendment”) is entered into, effective as of August 30, 2005 (the “Amendment Effective Date”), by and between Astellas US LLC (“Astellas”, successor-in-interest to Fujisawa Healthcare, Inc., the original signatory to the Agreement defined below), and CV Therapeutics, Inc. (“CVT”) (Astellas and CVT being individually referred to herein as a “Party” and collectively as the “Parties”), with reference to the following facts and circumstances:

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