0001193125-05-120013 Sample Contracts

REGISTRATION RIGHTS AGREEMENT
Registration Rights Agreement • June 3rd, 2005 • Biodelivery Sciences International Inc • Pharmaceutical preparations • New York

This Agreement is made pursuant to the Securities Purchase Agreement, dated as of the date hereof, by and between the Purchaser and the Company (as amended, modified or supplemented from time to time, the “Securities Purchase Agreement”), and pursuant to the Note and the Warrants referred to therein.

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Contract
Biodelivery Sciences International Inc • June 3rd, 2005 • Pharmaceutical preparations • New York

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. THIS WARRANT AND THE COMMON STOCK ISSUABLE UPON EXERCISE OF THIS WARRANT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THIS WARRANT UNDER SAID ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO BIODELIVERY SCIENCES INTERNATIONAL, INC. THAT SUCH REGISTRATION IS NOT REQUIRED.

Contract
Biodelivery Sciences International Inc • June 3rd, 2005 • Pharmaceutical preparations • New York

THIS NOTE AND THE COMMON SHARES ISSUABLE UPON CONVERSION OF THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. THIS NOTE AND THE COMMON SHARES ISSUABLE UPON CONVERSION OF THIS NOTE MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THIS NOTE UNDER SAID ACT AND ANY APPLICABLE STATE SECURITIES LAWS OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO BIODELIVERY SCIENCES INTERNATIONAL, INC. THAT SUCH REGISTRATION IS NOT REQUIRED.

SECURITIES PURCHASE AGREEMENT LAURUS MASTER FUND, LTD. and BIODELIVERY SCIENCES INTERNATIONAL, INC. Dated: May 31, 2005
Securities Purchase Agreement • June 3rd, 2005 • Biodelivery Sciences International Inc • Pharmaceutical preparations • New York

THIS SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of May 31st, 2005, by and between BIODELIVERY SCIENCES INTERNATIONAL, INC., a Delaware corporation (the “Company”), and LAURUS MASTER FUND, LTD., a Cayman Islands company (the “Purchaser”).

REAFFIRMATION AND RATIFICATION AGREEMENT AND AMENDMENT
Reaffirmation and Ratification Agreement • June 3rd, 2005 • Biodelivery Sciences International Inc • Pharmaceutical preparations • New York
GRANT OF SECURITY INTEREST IN PATENTS AND TRADEMARKS
Grant of Security Interest • June 3rd, 2005 • Biodelivery Sciences International Inc • Pharmaceutical preparations

THIS GRANT OF SECURITY INTEREST (“Grant”), effected as of May 31, 2005, is executed by BioDelivery Sciences International, Inc. a Delaware corporation (the “Grantor”), in favor of Laurus Master Fund, Ltd. (the “Secured Party”).

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