0001104659-11-013601 Sample Contracts

January 20, 2011 Francois-Xavier Frapaise PMB 80 P.O. Box 5000 Rancho Santa Fe, CA 92067 Re: Separation from Optimer Pharmaceuticals, Inc. Dear Xavier:
Optimer Pharmaceuticals Inc • March 10th, 2011 • Pharmaceutical preparations

This letter sets forth the terms and conditions of our agreement (the “Agreement”) regarding the termination of your employment with OPTIMER PHARMACEUTICALS, INC. (the “Company”). This Agreement shall be effective as of the Effective Date as defined in Section 15(d) herein. As part of this Agreement, and pursuant to and subject to the terms and conditions of the Company’s Amended and Restated Severance Benefit Plan (the “Severance Plan”), the Company is offering you the severance benefits outlined below. All initially capitalized terms not otherwise defined herein shall have the meaning ascribed to such terms in the Severance Plan.

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AMENDMENT TO API MANUFACTURING AND SUPPLY AGREEMENT
Api Manufacturing and Supply Agreement • March 10th, 2011 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations

This AMENDMENT TO API MANUFACTURING AND SUPPLY AGREEMENT (this “Amendment”), is entered into as of December 21, 2010 by and between OPTIMER PHARMACEUTICALS, INC. (“Optimer”) and BIOCON LIMITED (“Biocon”). Capitalized terms used herein which are not defined herein shall have the definitions ascribed to them in the Agreement (defined below).

OFFICE LEASE 101 HUDSON STREET JERSEY CITY, NEW JERSEY AGREEMENT OF LEASE between 101 HUDSON LEASING ASSOCIATES, Landlord and OPTIMER PHARMACEUTICALS, INC., Tenant
Office Lease • March 10th, 2011 • Optimer Pharmaceuticals Inc • Pharmaceutical preparations • New Jersey

This Reference Page is incorporated in and constitutes an integral part of this Lease. In addition to the other terms elsewhere defined in this Lease, the following terms wherever used in this Lease shall have the meanings set forth in this Reference Page.

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