0001104659-06-006249 Sample Contracts

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • February 6th, 2006 • Array Biopharma Inc • Services-medical laboratories

This First Amendment to Loan and Security Agreement (the “Amendment”) is entered into as of December 19, 2005, by and between COMERICA BANK (“Bank”) and ARRAY BIOPHARMA, INC. (“Borrower”).

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ADDENDUM #5 TO LEASE AGREEMENT
Lease Agreement • February 6th, 2006 • Array Biopharma Inc • Services-medical laboratories

THIS ADDENDUM #5 TO LEASE AGREEMENT, dated as of December 2, 2005, is entered into by and between CIRCLE CAPITAL LONGMONT LLC, a Delaware limited liability company (“Landlord”) and ARRAY BIOPHARMA, INC., a Delaware corporation (“Tenant”).

DRUG DISCOVERY AGREEMENT
Drug Discovery Agreement • February 6th, 2006 • Array Biopharma Inc • Services-medical laboratories • Colorado

THIS DRUG DISCOVERY AGREEMENT (the “Agreement”), is made and entered into, effective as of November 1, 2005 (the “Effective Date”), by and between Ono Pharmaceutical Co., Ltd., a Japanese corporation having a principal place of business at 8-2 Kyutaromachi 1-Chome, Chuo-Ku Osaka 541-8564, JAPAN (“ONO”), and Array BioPharma Inc., a Delaware corporation having a principal place of business at 3200 Walnut Street, Boulder, Colorado 80301, USA (“ARRAY”).

SECOND AMENDMENT TO DRUG DISCOVERY COLLABORATION AGREEMENT
Discovery Collaboration Agreement • February 6th, 2006 • Array Biopharma Inc • Services-medical laboratories

THIS AMENDMENT NO. 2 (“Second Amendment”), effective as of October 1, 2005 (Amendment Date”), is entered into by and between Genentech, Inc., a Delaware corporation, having a principal place of business at 1 DNA Way, South San Francisco, California 94080 (“Genentech”) and Array BioPharma Inc., a Delaware corporation, having a principal place of business at 3200 Walnut Street, Boulder, Colorado 80301 (“Array”) (collectively, the “Parties” or individually, a “Party”).

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