0001104506-21-000015 Sample Contracts

INSMED INCORPORATED PERFORMANCE-BASED RESTRICTED STOCK UNIT AWARD AGREEMENT UNDER THE 2019 INCENTIVE PLAN FOR U.S. GRANTEES
Restricted Stock Unit Award Agreement • October 28th, 2021 • INSMED Inc • Pharmaceutical preparations

Pursuant to the Insmed Incorporated 2019 Incentive Plan (the “Plan”) as amended through the date hereof and this Performance-Based Restricted Stock Unit Award Agreement (together with Exhibit A attached hereto, this “Agreement”), Insmed Incorporated (the “Company”) hereby grants an award of performance-based restricted stock units (the “PSUs” or the “PSU Award”) to the individual named above (the “Grantee”). The target number of PSUs subject to this PSU Award is /$AwardsGranted$/ (the “Target PSUs”). Each PSU corresponds to the right to receive one share of Common Stock, subject to the restrictions and conditions set forth herein and in the Plan. The actual number of PSUs that will vest and be settled into shares of Common Stock pursuant to this PSU Award shall depend on the achievement of the performance goals described in Exhibit A attached hereto (the “Vesting Schedule”) during the Performance Period (as defined in the Vesting Schedule). All terms used herein that are defined in the

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INSMED INCORPORATED AMENDMENT TO RESTRICTED UNIT AWARD AGREEMENT UNDER THE 2019 INCENTIVE PLAN FOR U.S. EMPLOYEES
Restricted Unit Award Agreement • October 28th, 2021 • INSMED Inc • Pharmaceutical preparations

This Amendment to Restricted Unit Award Agreement under the 2019 Incentive Plan for U.S. Employees (this “Amendment”) is entered into as of [●], 2021 (the “Effective Date”) by and between Insmed Incorporated (the “Company”) and [●] (the “Grantee”). All terms used herein that are defined in the Insmed Incorporated 2019 Incentive Plan (as amended through the date hereof, the “Plan”) or the Agreement (defined below) have the same meaning given to them in the Plan or the Agreement, respectively.

INSMED INCORPORATED NON-QUALIFIED STOCK OPTION AGREEMENT UNDER THE 2019 INCENTIVE PLAN
Non-Qualified Stock Option Agreement • October 28th, 2021 • INSMED Inc • Pharmaceutical preparations • Virginia

THIS AGREEMENT dated this /$GrantDate$/, between INSMED INCORPORATED, a Virginia corporation (the "Company"), and /$ParticipantName$/ ("Participant"), is made pursuant and subject to the provisions of the Insmed Incorporated 2019 Incentive Plan, as amended (the "Plan"), a copy of which has been made available to the Participant. All terms used herein that are defined in the Plan have the same meaning given them in the Plan.

INSMED INCORPORATED RESTRICTED UNIT AWARD AGREEMENT UNDER THE 2019 INCENTIVE PLAN FOR U.S. EMPLOYEES
Insmed Incorporated • October 28th, 2021 • INSMED Inc • Pharmaceutical preparations

Pursuant to the Insmed Incorporated 2019 Incentive Plan (the “Plan”) as amended through the date hereof and this Restricted Stock Unit Award Agreement (this “Agreement”), Insmed Incorporated (the “Company”) hereby grants an award of /$AwardsGranted$/ restricted stock units (the “Restricted Stock Units” or the “RSU Award”) to the individual named above (the “Grantee”). The RSU Award shall be referred to herein as the “Award.” Subject to the restrictions and conditions set forth herein and in the Plan, the Grantee shall receive the number of Restricted Stock Units specified above. All terms used herein that are defined in the Plan have the same meaning given them in the Plan.

INSMED INCORPORATED PERFORMANCE-BASED RESTRICTED STOCK UNIT AWARD AGREEMENT UNDER THE 2019 INCENTIVE PLAN FOR NON-U.S. GRANTEES
Performance-Based Restricted Stock Unit Award Agreement • October 28th, 2021 • INSMED Inc • Pharmaceutical preparations

Pursuant to the Insmed Incorporated 2019 Incentive Plan (the “Plan”) as amended through the date hereof and this Performance-Based Restricted Stock Unit Award Agreement (together with Exhibit A attached hereto, this “Agreement”), Insmed Incorporated (the “Company”) hereby grants an award of performance-based restricted stock units (the “PSUs” or the “PSU Award”) to the individual named above (the “Grantee”). The target number of PSUs subject to this PSU Award is /$AwardsGranted$/ (the “Target PSUs”). Each PSU corresponds to the right to receive one share of Common Stock, subject to the restrictions and conditions set forth herein and in the Plan. The actual number of PSUs that will vest and be settled into shares of Common Stock pursuant to this PSU Award shall depend on the achievement of the performance goals described in Exhibit A attached hereto (the “Vesting Schedule”) during the Performance Period (as defined in the Vesting Schedule). All terms used herein that are defined in the

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