0001047469-16-013774 Sample Contracts

Gemphire Therapeutics Inc. UNDERWRITING AGREEMENT
Underwriting Agreement • June 13th, 2016 • Gemphire Therapeutics Inc. • Pharmaceutical preparations • New York
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EMPLOYMENT AGREEMENT
Employment Agreement • June 13th, 2016 • Gemphire Therapeutics Inc. • Pharmaceutical preparations • Michigan

THIS EMPLOYMENT AGREEMENT (this “Agreement”) by and between GEMPHIRE THERAPEUTICS INC., a Delaware corporation (the “Company”) and [ ] (the “Executive”) is signed by the Company and the Executive on [ ], 201[_], and is made effective as of the IPO Date (the “Effective Date”).

POWERSCOURT OFFICE BUILDING LEASE
Lease • June 13th, 2016 • Gemphire Therapeutics Inc. • Pharmaceutical preparations

THIS LEASE is made between the Landlord and Tenant hereinafter identified in Paragraph 1(b) and 1(c) hereof, respectively, and constitutes a Lease between the parties of the “demised premises” in the “Building” as defined in Paragraph 2 hereof on the terms and conditions and with and subject to the covenants and agreements of the parties hereinafter set forth.

LICENSE AGREEMENT
License Agreement • June 13th, 2016 • Gemphire Therapeutics Inc. • Pharmaceutical preparations • New York

THIS LICENSE AGREEMENT (“Agreement”) is made effective as of the 16th day of April, 2011 (the “Effective Date”), by and between Michigan Life Therapeutics, LLC a corporation organized and existing under the laws of Michigan with offices at 2020 Shadford Road, Ann Arbor, MI 48104 (“LICENSEE”) and Pfizer Inc., a corporation organized and existing under the laws of Delaware with offices at 235 East 42nd Street, New York, NY 10017 (“PFIZER”). LICENSEE and PFIZER may, from time-to-time, be individually referred to as a “Party” and collectively referred to as the “Parties”.

GEMPHIRE THERAPEUTICS INC. FOURTH AMENDMENT TO NOTE PURCHASE AGREEMENT AND CONVERTIBLE PROMISSORY NOTES
Note Purchase Agreement • June 13th, 2016 • Gemphire Therapeutics Inc. • Pharmaceutical preparations

THIS FOURTH AMENDMENT TO NOTE PURCHASE AGREEMENT AND CONVERTIBLE PROMISSORY NOTES (this “Fourth Amendment”) is made effective as of this 26th day of April 2016 (the “Fourth Amendment Date”), by and among GEMPHIRE THERAPEUTICS INC., a Delaware corporation (the “Company”), and the purchasers of the Company’s Convertible Promissory Notes identified on the signature page attached hereto (the “Purchasers”).

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