0001047469-13-001388 Sample Contracts

AMENDMENT NO. 2 TO COLLABORATION AGREEMENT
Collaboration Agreement • February 21st, 2013 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

This AMENDMENT NO. 2 TO THE COLLABORATION AGREEMENT (the “Amendment”) is entered into and effective on this 8th day of January, 2013 (the “Second Amendment Effective Date”), by and between Ironwood Pharmaceuticals, Inc. a Delaware corporation (formerly Microbia, Inc.) (“Ironwood”) and Forest Laboratories, Inc. (“Forest”). Ironwood and Forest may each be referred to herein individually as a “Party” and collectively as the “Parties.”

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SIXTH AMENDMENT TO LEASE
Lease • February 21st, 2013 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS SIXTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 19th day of July, 2012 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

COLLABORATION AGREEMENT by and between IRONWOOD PHARMACEUTICALS, INC. and ASTRAZENECA AB October 23, 2012
Collaboration Agreement • February 21st, 2013 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS COLLABORATION AGREEMENT (the “Agreement”) is entered into on this 23rd day of October, 2012 (the “Effective Date”), by and among Ironwood Pharmaceuticals, Inc., a corporation organized under the laws of Delaware (“Ironwood”) and AstraZeneca AB, a corporation organized under the laws of Sweden (“AstraZeneca”). Ironwood and AstraZeneca may be referred to in this Agreement individually as a “Party” and collectively as the “Parties.”

SEVENTH AMENDMENT TO LEASE
Lease • February 21st, 2013 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS SEVENTH AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 30th day of October, 2012 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

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