0001047469-10-002966 Sample Contracts

SECOND AMENDMENT TO LEASE
Lease • March 30th, 2010 • Ironwood Pharmaceuticals Inc • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE (this “Amendment”) is entered into as of this 9th day of February, 2010 (the “Execution Date”), by and between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord,” as successor-in-interest to Rogers Street, LLC (“Original Landlord”)), and IRONWOOD PHARMACEUTICALS, INC., a Delaware corporation (formerly known as Microbia, Inc.) (“Tenant”).

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