QuickLinks -- Click here to rapidly navigate through this documentVertex Pharmaceuticals Inc / Ma • November 9th, 2007 • Pharmaceutical preparations • Massachusetts
Your expertise, reputation and position make you a key member of the senior management team of Vertex Pharmaceuticals Incorporated (the "Company"). As a result, the Company would like to provide you with the following "change of control" benefit to help ensure that in the event the Company becomes involved in a "change of control" transaction, there will be no distraction from your attention to the needs of the Company.
