0001035704-06-000247 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • April 5th, 2006 • Replidyne Inc • Colorado

This Employment Agreement (the “Agreement”) is made as of this 3rd day of April, 2006, by and between Replidyne, Inc., (the “Company”), and Roger Echols (“Employee”) (collectively, the “Parties”).

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LEASE
Lease • April 5th, 2006 • Replidyne Inc • Connecticut

THIS LEASE (this “Lease”) dated the 22nd day of March 2005, by and between CROWN MILFORD LLC, a Delaware limited liability company having an address at c/o Crown Properties, Inc., 400 Garden City Plaza, Garden City, NY 11530 (“Landlord”) and REPLIDYNE, INC., a Delaware corporation having an office at 1450 Infinite Drive, Louisville, Colorado 80027 (“Tenant”).

SECOND AMENDMENT TO LICENSE AGREEMENT
License Agreement • April 5th, 2006 • Replidyne Inc

This Second Amendment (the “Amendment”) is entered into as of February 10, 2006 (the “Second Amendment Date”) to modify the terms of the License Agreement (the “License Agreement”) dated as of March 15, 2004 (as first amended April 5, 2005), by and between DAIICHI ASUBIO PHARMA CO., LTD., a corporation organized and existing under the laws of Japan and having its registered office at 9-11, Akasaka 2-chome, Minato-ku, Tokyo 107-8541, Japan (hereinafter referred to as “DAP”) and REPLIDYNE, INC., a corporation organized and existing under the laws of the State of Delaware, having its principal business office at 1450 Infinite Drive, Louisville, Colorado 80027, U.S.A. (hereinafter referred to as “REPLIDYNE”). DAP and REPLIDYNE are sometimes referred to collectively herein as the “Parties” or individually as a “Party.”

Contract
Supply Agreement • April 5th, 2006 • Replidyne Inc • New York

[ *** ] = Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Exchange Act Of 1933, as amended.

LICENSE AGREEMENT
License Agreement • April 5th, 2006 • Replidyne Inc • New York

This License Agreement (hereinafter referred to as the “Agreement”) made and entered into as of March 15, 2004 (hereinafter referred to as the “Effective Date”) by and between DAIICHI SUNTORY PHARMA CO., LTD., a corporation organized and existing under the laws of Japan and having its registered office at 7-2, Kojimachi 5-chome, Chiyoda-ku, Tokyo 102-8530, Japan (hereinafter referred to as “DSP”) and REPLIDYNE, INC., a corporation organized and existing under the laws of the State of Delaware, having its principal business office at 1450 Infinite Drive, Louisville, Colorado 80027, U.S.A. (hereinafter referred to as “REPLIDYNE”). DSP and REPLIDYNE are sometimes referred to collectively herein as the “Parties” or individually as a “Party”.

Replidyne, Inc (a Delaware corporation) INDEMNIFICATION AGREEMENT FOR OFFICERS
Indemnification Agreement for Officers • April 5th, 2006 • Replidyne Inc • Delaware

This Indemnification Agreement (“Agreement”) is entered into as of the [___] day of [___] 200[___] by and between Replidyne, Inc., a Delaware corporation (the “Company”) and the officer of the Company identified on the signature page hereto (the “Officer” or “Indemnitee”).

LEASE
Lease • April 5th, 2006 • Replidyne Inc

THIS LEASE (“Lease”), dated as of October 25, 2005, is made by and between TRIUMPH 1450 LLC, a Colorado limited liability company (“Landlord”), and REPLIDYNE, INC., a Delaware corporation (“Tenant”) (collectively, the “Parties,” and individually, a “Party”).

Replidyne, Inc (a Delaware corporation) INDEMNIFICATION AGREEMENT
Indemnification Agreement • April 5th, 2006 • Replidyne Inc • Delaware

This Indemnification Agreement (“Agreement”) is entered into as of the [___] day of [___] 200[___] by and between Replidyne, Inc., a Delaware corporation (the “Company”) and the director of the Company identified on the signature page hereto (the “Director”; collectively with such Director’s Affiliated Persons (as defined in Section 10(a) hereof, the “Indemnitee” or the “Indemnitees”).

AMENDMENT TO LICENSE AGREEMENT
License Agreement • April 5th, 2006 • Replidyne Inc

This Amendment (the “Amendment”) is entered into as of April 5, 2005 (the “Effective Date”) to modify the terms of the License Agreement (the “License Agreement”) dated as of March 15, 2004 by and between DAIICHI SUNTORY PHARMA CO., LTD., a corporation organized and existing under the laws of Japan and having its registered office at 7-2, Kojimachi 5-chome, Chiyoda-ku, Tokyo 102-8530, Japan (hereinafter referred to as “DSP”) and REPLIDYNE, INC., a corporation organized and existing under the laws of the State of Delaware, having its principal business office at 1450 Infinite Drive, Louisville, Colorado 80027, U.S.A. (hereinafter referred to as “REPLIDYNE”). DSP and REPLIDYNE are sometimes referred to collectively herein as the “Parties” or individually as a “Party.”

REPLIDYNE, INC. FOURTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT
Stockholders Agreement • April 5th, 2006 • Replidyne Inc • Delaware

THIS FOURTH AMENDED AND RESTATED STOCKHOLDERS AGREEMENT (this “Agreement”) is entered into as of August 17, 2005, by and among REPLIDYNE, INC., a Delaware corporation (the “Corporation”), those original stockholders of the Corporation listed on Schedule 1 hereto (hereinafter referred to collectively as the “Original Stockholders”), those stockholders of the Corporation listed on Schedule 2 hereto (hereinafter referred to collectively as the “Investors”), those certain stockholders of the Corporation that shall from time-to-time become party to this Agreement effective as of the date indicated on the counterpart signature page hereto (together with the Original Stockholders and Investors, the “Holders”) and the holders of the Warrants listed on Schedule 3 hereto (the “Warrant Holders”).

COLLABORATION AND COMMERCIALIZATION AGREEMENT
Collaboration and Commercialization Agreement • April 5th, 2006 • Replidyne Inc • New York
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